Principal Scientist I Precision Medicine Translational Research Immunology
Principal Scientist I Precision Medicine Translational Research Immunology
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Job Description
We are seeking a highly motivated and creative Scientist with a scientific background in immunology or immunooncology to join Precision Medicine Translational Research Immunology Group as Principal Scientist at AbbVie. The candidate will provide leadership in clinical biomarker strategy and assay development in inflammatory/autoimmune disease areas including Dermatology Gastroenterology Rheumatology and Fibrosis for AbbVies drug development programs from late discovery to clinical trials. The successful candidate will be part of a growing translational research group working with crossdisciplinary teams both internally and externally.
Key Responsibilities:
- Lead biomarker strategies through crossfunctional teams in a matrix environment to identify gaps and develop fitforpurpose clinical TE/PD biomarker predictive and exploratory biomarker assays to support human dose projection and establish early signs of efficacy in clinical trials and patient selection strategies.
- Collaborate with Data Science team and Precision Medicine lead to analyze internal and external omics data understand heterogeneity of diseases identify disease endotypes support disease strategy and generate patient selection and combination hypotheses for further testing with preclinical studies.
- Develop preclinical patient derived disease models design studies with appropriate controls and endpoints to understand drug target mechanisms for PD biomarker development and evaluate biomarker hypotheses and combination strategies.
- Serve as a subject matter expertise in analytical methodologies/technologies for translational research including single cell and spatial omics proteomics methylomics metabolomics genomics NGS MSD ELISA Luminex flow cytometry ex vivo primary cell culture and organoidimmune cell culture.
- Manage external CROs and academic collaborations including study proposal budget timeline and data review.
- Manage and coach a team of translational scientists ensuring the successful of translational research plans across multiple projects.
- Keep abreast of latest research & development in inflammatory and immune diseases through critically reviewing literature attending conferences and seeking advice from KOLs.
Qualifications :
- Major or advanced degree in Immunology cell & molecular biology pharmacology pathology bioinformatics or other relevant biological sciences. B.S. & typically 14 years M.S. & typically 12 years Ph.D. or equivalent & typically 8 years of relevant industrial biotechnology experience.
- Experience in leading translational medicine in Rheumatological diseases (RA SLE SSc) is a plus.
- Expertise in a broad range of translational technologies data analytics and computational tools.
- Proficient in multiparameter flow cytometry including spectral flow cytometry and analytical software (e.g. BD FACSDiva Flowjo OMIQ) to analyze different immune cell types and cell states from mice human and cynomolgus monkey.
- Experienced in designing and conducting single cell omics spatial omics genomicbased assays and developing analytical workflow to generate or validate biomarker hypotheses.
- Knowledgeable with integrative analysis of multidimensional datasets using bioinformatics tools and methods (e.g. R Python SQL AI/ML HPC and cloud environments)
- Strong project leadership and organizational skills to prioritize tasks and allocate resources to meet projects goals in a tight timeline.
- Experienced in managing CROs and collaborators facilitating meetings and working independently and collaboratively with multifunctional teams in a dynamic and fast paced environment.
- Demonstrated ability to supervise and coach direct reports.
- Excellent communication presentation organizational and people management skills
- Strong trackrecord of scientific publications from peer reviewed journals and presentations in major conferences
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our shortterm incentive programs.
- This job is eligible to participate in our longterm incentive programs
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race color religion national origin age sex (including pregnancy) physical or mental disability medical condition genetic information gender identity or expression sexual orientation marital status status as a protected veteran or any other legally protected group status.
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No
Employment Type :
Fulltime
Employment Type
Full-time
