Staff Scientist Senior Manager Quality Control Analytical Development
Staff Scientist Senior Manager Quality Control Analytical Development
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Salary Not Disclosed
1 Vacancy
Job Description
About Glyphic:
At Glyphic Biotechnologies we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel singlemolecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date we have raised >$50M from venture partners and nondilutive grant funding to achieve our vision of next generation proteome sequencing.
What we are looking for in you:
Glyphic is seeking an experienced quality and analytical development leader who will report to the Chief Operating Officer and anchor a newly formed Quality Control & Analytical Development team focused on establishing an internal core facility to centralize Glyphics current analytical development activities while building out a phase appropriate Quality Control program in support of a commercial launch. This will be a unique opportunity to design and implement new analytical processes build out a dedicated lab and see your contributions directly translate into the creation and commercialization of advanced proteomic and genomic analysis platforms.
The ideal candidate will have a strong background in analytical chemistry specifically in the operation and troubleshooting of LCMS and HPLC systems for the characterization of oligonucleotides peptides and small molecules and the productization of complex life science platforms or instruments. Experience with method development data interpretation and regulatory compliance is highly desirable. This position requires the candidate to be handson in procuring and operating advanced analytical instrumentation while working with a crossdisciplinary team of chemists biologists engineers and bioinformaticians to rapidly deliver consistent results and insights that accelerate the development cycle.
Responsibilities:
Execute analytical testing using LCMS HPLC and CE instruments for protein and nucleic acid characterization and purity assessment.
Establish and operate a new QC & AD core to support instrument and assay development
Develop optimize and validate analytical methods to characterize novel protein sequencing instrumentation and production processes
Implement and oversee phaseappropriate inline quality control processes and monitoring programs
Establish and perform QC testing for raw materials and finished products
Support investigations for outofspecification results including root cause analysis corrective action implementation and detailed investigation reports.
Support stability studies and comparability programs
Establish and maintain a phaseappropriate environmental monitoring program
Generate quality metrics reports analyzing testing volumes turnaround times and trends in analytical results.
Manage QC sample storage retention and disposal according to safety protocols particularly for hazardous materials.
Author and review study protocols and reports as well as documentation to comply with regulatory and audit requirements
Required Competencies:
Advanced degree in Chemistry Analytical Chemistry Biochemistry or related field
8 years in analytical development or protein characterization with quality control experience
Proven track record operating and maintaining LCMS HPLC CE systems independently
Deep understanding of separation science mass spectrometry spectrophotometry electrophoresis
Proficiency in statistical analysis and report generation
Experience with analytical method development optimization validation
Demonstrated complex troubleshooting (instrument method sample prep issues)
Strong technical writing (SOPs reports investigations)
Proven ability to manage multiple timesensitive projects supporting crossfunctional stakeholders
Preferred Competencies:
Proficiency in Agilent BioConfirm software
Proficiency in Atlassian tools for project management
Benefits and Perks:
Employee Stock Option Plan
100 Health Plan Coverage for Employees & Dependents (Medical Dental & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities
We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race color religion national origin age sex marital status ancestry physical or mental disability veteran status gender identity or sexual orientation.
Required Experience:
Senior Manager
Employment Type
Full-Time
