Research Scientist
Research Scientist
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Job Description
Jobdescription
The Xavier group is in search of ahighly motivated and capable Research Scientist to join our multidisciplinaryteam working on targeting theregulatory networks governing gut mucosal immune responses for therapeuticimpact. The primary role involves a combination of cellular pharmacologyand target validation studies. This includes the development and implementationof critical experiments for target validation of autophagy genes linked toinflammation by genetic studies cellbased assay development andimplementation and the development of approaches to assess mechanism ofaction.
Characteristicduties
Design plan andexecute cellbased biochemical and invivo experiments necessary to validate target genes for therapeutic discovery.
Maintaincell lines and isolate primary cells for use in cellbased assays.
Workwith informatics and computational scientists to integrate and interpretscreening and functional genomic data sets.
Performdetailed characterization and cellular mechanism of action studies ofchemically optimized compounds.
Workwith team to design and execute research plans to ensure that critical projectrequirements timelines and deliverables are met.
Troubleshootand solve scientific problems independently.
Identifyinvestigate and implement new technologies based on scientific needs.
Effectivelypresent results in crossfunctional project teams.
Requirements
Ph.D. in Biology Molecular and Cell Biology Biochemistry Microbiology Immunology or a related life science field with at least 4 years of research experience in an academic setting focusing on autophagy innate immunity or hostpathogen interactions.
Excellent publication record
A proven record of successful interactions within multidisciplinary teams.
Cellbased assay development experience is required with special emphasis on functional genomic methods for target validation (e.g. shRNA CRISPR).
Significant experience in cell culture techniques including use of mammalian cell lines and primary human cells. Experience working with mouse models is a plus.
The successful candidate will be a resultsfocused teamoriented creative bench scientist able to excel in a fasttrack environment. He or she must be selfmotivated detailoriented and exhibit strong problem solving skills. In addition the successful candidate should be a clear and effective communicator demonstrating strong interpersonal skills to enable collaboration with project teams peers and management in identifying and achieving research goals.
Employment Type
Full-Time
