Principal Scientist - Upstream Process Development - Onsite - Marlborough MA
Principal Scientist - Upstream Process Development - Onsite - Marlborough MA
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Salary Not Disclosed
1 Vacancy
Job Description
What you will accomplish together with us:
- Design and optimize protocols for the culture and growth of primary cells and cell lines (e.g. HEK CHO and Vero) using cuttingedge techniques aimed at enhancing the efficiency and scalability of the processes.
- Lead crossfunctional teams to scale primary cell and cell line expansion and from benchtop to production scale bioreactors.
- Develop and write process development proposals conduct handson laboratory work to optimize and troubleshoot upstream manufacturing processes for Viral Vectors mAbs and other biologics.
- Analyze and interpret data ensuring clear documentation of methodologies and outcomes.
- Prepare detailed reports and presentations for internal and external partners to communicate progress in line with project schedules.
- Assist in mentoring and training junior team members and coordinating the daytoday operations.
- Lead and manage multiple high impact internal and external research projects by establishing priorities milestones schedules and deadlines.
- Responsible for writing reviewing and maintaining electronic lab notebooks with the highest level of research integrity.
- Responsible for writing project reports briefs protocols and making presentations to internal and external partners and project teams as required.
- Lead technology transfer activities to internal and external collaborators.
- Support marketing efforts by writing technical briefs application notes and peer reviewed publications leading or assisting with technical presentations at scientific conferences.
- Conduct technical investigations and risk assessments related to processes.
- Support generation of protocols work instructions batch records and reports.
- Work independently in a matrixed environment.
- Perform occasional extended hours and weekends to support ongoing lab activities as needed.
- Mentor and support junior staff and build a culture of support and collaboration.
- Comply with all site policies such as record retention ISO requirements and accountable for good housekeeping in all laboratories.
- Comply with biohazard special clean room and site safety/health procedures and guidelines as required.
- Assist other team members and site management team with miscellaneous duties when requested.
What will convince us:
Education:
- Ph.D. (with 6 years of industry experience) in chemical biochemical or biomedical engineering engineered cell therapies or related field.
Experience:
- Extensive expertise in culturing cell types relevant to advanced therapy applications.
- Expertise in adapting existing cell culture processes from planar to 3D bioreactor systems.
- Handson experience with microcarrierbased suspension culture and single cell cloning is a plus.
- Knowledge of GxPs experience in process development or GMP operation is a plus.
- Demonstrated ability to design plan and implement pluripotent cell differentiation protocols.
- Experience in the design and of current molecular biology and biochemical assay techniques including PCR qPCR ddPCR NGS WB IF ELISA and Flow Cytometry is highly desirable.
- Experience & knowledge of stateof theart upstream and downstream technologies for cell growth transfection propagation and purification for application for process development workflow.
- Experience working as part of multipartner R&D projects.
- Experience with documentation control systems.
- Familiarity with relevant guidelines from the FDA EMA and ICH
- Working Conditions/Environment (ex. Any irregular or unusual work schedules travel etc):
- Travel 1020 of time both foreign and domestic. Work on weekends as required. Work in a Biosafety Level 2 Laboratory.
We value:
- Strong analytical and mathematical ability.
- Ability to work independently and constructively in a team environment.
- Must have strong personal initiative and be results oriented.
- Strong troubleshooting skills.
- Strong written and verbal English communication skills capable of clearly expressing technical concepts to people with various levels of technical expertise and diverse cultural backgrounds.
- Identification with our core values: Sustainability Openness Enjoyment
What We Offer
As a growing global life science company with our stock listed on the German DAX and TecDAX Sartorius offers a wide range of benefits:
Personal and Professional Development: Mentoring leadership programs internal seminar offerings
Worklife Balance: Paid vacation sick time corporate holidays and community service day; as well as flexible work schedules
Making an Impact Right from the Start: Comprehensive onboarding including a virtual online platform
Welcoming Culture: Mutual support team spirit and international collaboration; communities on numerous topics such as Coaching Agile Working and a Businesswomens Network
Health & Well Being: Wide selection of health and wellbeing support such as a variety of medical plans to choose from dental vision EAP and other wellness programs.
Intelligent Working Environment: Working in smart buildings with the latest technology and equipment.
Retirement Savings Plan: 401 k (with generous company match)
Flexible Spending: HSA FSA (dependent care & healthcare spending) Transportation Commuter Account
Company Paid Benefits: Basic Life Insurance AD&D EAP Family Planning & Womens Health Health Advocate
Additional/Optional: Supplemental Life Insurance (employee spouse & dependents) Legal Services LTD & STD Critical Illness Insurance Student Loan Tuition Refinance Service
All qualified applicants will be considered for employment without regard to race color religion sex or national origin. We are also an equal opportunity employer of individuals with disabilities and protected veterans.
Please view equal employment opportunity posters provided by OFCCP here.
Sartorius is part of the solution in the fight against cancer dementia and many other diseases. Our technologies help translate scientific discoveries into realworld medicine faster so that new therapeutics can reach patients worldwide. We look for ambitious team players and creative minds who want to contribute to this goal and advance their careers in a dynamic global environment. Join our global team and become part of the solution. We are looking forward to receiving your application.
We look forward to receiving your application.
Sartorius is an Equal Opportunity/Affirmative Action employer and will consider all qualified applicants for employment without regard to race color religion gender sexual orientation gender identity national origin age protected veteran status or disability status.
All employment decisions are based on valid jobrelated requirements.
If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website you may request a reasonable accommodation to express interest in a specific opening. You can request reasonable accommodation by calling 1 ext 8330 or via email at
About Sartorius
Sartorius is part of the solution in the fight against cancer dementia and many other diseases. Our technologies help translate scientific discoveries into realworld medicine faster so that new therapeutics can reach patients worldwide.
We look for ambitious team players and creative minds who want to contribute to this goal and advance their careers in a dynamic global environment.
Join our global team and become part of the solution. We are looking forward to receiving your application.
www.sartorius/careers
Required Experience:
Staff IC
Employment Type
Full-Time
