Scientist- Preclinical Design and Development Core
Scientist- Preclinical Design and Development Core
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$ 86320 - 154960
1 Vacancy
Job Description
St. Jude Childrens Research Hospital is excited to announce an opening for a Scientist to join our dedicated team! This is a fantastic opportunity for those interested in developing personalized genomic therapies as part of the Preclinical Design and Development Core (PDD Core) integral to the Pediatric Translational Neuroscience Initiative at St. Jude. We design genomic therapies for children with catastrophic diseases particularly those affecting the developing nervous system as these hold immense potential for promoting longer survival improved function and enhanced quality of life. At the core we are leading the scientific operations under St Judes new Bluesky program GEMINI (Genomic Medicine Initiative) to develop therapeutics for these rare neurodegenerative disorders.
As a scientist in the Preclinical Design and Development Core (PDD core) you will apply your efforts in designing therapeutic approaches identifying the lead therapeutics molecule contributing to the therapeutic approval process and observing the clinical impact of the drug a complete bench to bedside process.
In this role you will lead projects that include:
Engineer personalized oligonucleotide therapeutics for cases enrolled in the GEMINI program.
Utilize patientderived in vitro platforms including iPSC and 2D/3D neuronal models to screen candidate molecules.
Identify the lead drug molecule that will be utilized for the treatment of specific patients.
Develop laboratory automation workflows to perform scalable oligonucleotide screening.
What will you gain in this role:
Being a key contributor to the development of personalized therapeutics from patient mutation identification to lead oligonucleotide molecule discovery for clinical treatment.
Skills including ASO therapeutics antisense biology scalable drug screening patientderived iPSCs and neuron platforms highthroughput genomics and liquid handling automation.
Prior experience in highthroughput molecular assays using hiPSC/derived neuron models or 3D organoids would be a plus.
The job responsibilities include but are not limited to:
Establishing neurodegenerative disease models to facilitate scalable oligonucleotide discovery using patientderived iPSC/neurons/3D brain organoids.
Coordinate and execute the design and testing of candidate drug molecules in patientderived platforms (fibroblasts iPSCs and iPSCderived neurons).
Contribute to the development of individualized therapeutics involving various aspects of preclinical processes and general operations.
Operating and troubleshooting liquid handler automation and robotics for high throughput cellbased assays and qPCR 384well format).
Clearly communicate with internal and external stakeholders (including strategy groups and industry partners). Represent the lab to present results across various internal and external forums.
Support monitoring of supplies and maintenance/calibration of equipment.
Maintain electronic laboratory notebook and paper notebook system to document all laboratory activities.
Perform other related duties to meet the goals of the department and institution.
Minimum Education and/or Training for the position include:
Bachelors degree in a relevant scientific area is .
Scientist Minimum Experience:
Eight 8 years of relevant work experience is required.
Six 6 years of relevant work experience is with a Masters degree.
Three 3 years of relevant work experience is with a PhD.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86320 $154960 per year for the role of Scientist Preclinical Design and Development Core.Explore our exceptional benefits!
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Employment Type
Full-Time
