Research Technician II
Research Technician II
Posted on :
09-04-2025
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1 Vacancy
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Job Description
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills perspectives and ideas we choose to lead. Applications fromprotected veterans and individuals with disabilities are strongly encouraged. GENERAL SUMMARY/ OVERVIEW STATEMENT: Provide operational supports to the Director/Manager of Islet Isolation cGMP Laboratory at MGH. Be trained on and adhere to Standard Operating Procedures (SOPs) that apply to human islet manufacture preparation; manufacturing; conducting QC assays and laboratory operation. Provide technical support to activities that pertain to the human islet manufacturing processes and quality control assays. Perform large animal and rodent islet isolation and quality control assays. Perform duties related to basic science research. PRINCIPAL DUTIES AND RESPONSIBILITIES: Human Islet Manufacturing Supporting Responsibilities:(In conjunction with other team members or independently) Receive inspect document collect COA or certificate of compliance/sterilization and store supplies as indicated in SOPs. Washing and sterilization of reusable items such as screens gradient makers marbles digestion chamber and etc as indicated in SOPs. Restock the supplies after each islet isolation Organize the facilitys furniture equipment cabinet and shelves in a professional way. Document all equipment maintenance log; Maintain all the incubators and waters bath as indicated in SOPs. Remove waste and organize islet isolation facility after each isolation as indicated in SOPs. Supervise the contractor who provides the monthly facility clean documentation of the service work as indicated in SOPs: Perform the weekly clean room disinfect procedure as indicated in SOPs. Exchange surgical gowns for the team Check facility monitoring system on daily basis and document any unusually activities based on SOP. Assists with other duties as required. Human Islet Manufacturing Responsibilities:(In conjunction with other team members or independently) Working closely with team member in all activities that pertain to the human islet manufacturing processes required for clinical islet transplantation. Setting up the laboratory for islet manufacture as indicated in SOPs; Performing environmental monitoring( viable and noviable); Cleaning hoods before during and after the isolations as indicated in the SOP. Preparing the solutions for islet isolation and handling the tissue as indicated in SOPs. Deliver microbiology samples to the Microbiology Lab of MGH. Preparing the FDAPI Dithionate dye before each isolation. Culturing and Distributing tissue to investigator as indicated in SOPs. Assists with other duties as required. Quality Control Responsibilities: Treat INS DNA and histology samples as indicated in SOPs. Labeling and storage samples as indicated in SOPs. Perform Glucose Stimulated Insulin Release as indicated in SOPs Perform INS quantification assay(ELISA)as indicated in SOPs Perform DNA quantification assay as indicated in SOPs Perform Endotoxin assay as indicated in SOPs Submit original test results to the Director/Manager of the islet isolation laboratory. Large Animal and Rodent Islet Isolation: Work closely with team member or independently to perform all activities that pertain to the large animal pancreases procurement and islet isolation. Prepare solutions needed for islet isolation; Organize the lab before and after each isolation Culture and Distribute tissue to investigator. Perform bioassays or tests for quality control. Data management Responsibilities: Enter isolation data into labs database. Enter islet distribution data into labs data basis Basic Science research: Execute protocols of routine molecular and immunology assays Perform basic design and modification of protocols when necessary Organize and summarize acquired data using scientific and statistical techniques Prepare and present reports of experiments Assists with other duties as required. QUALIFICATIONS: Bachelors degree with 12 years related work experienceexposure to cGMP practice is highly desirable. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: MANUAL DEXTERITY REQUIRED:Mobility to perform keyboarding skills dexterous with both hands to perform daily activities and able to lift 60 pounds. Time Management: Exceptional organizational skills and ability to organize time and priorities effectively asking for direction when appropriate. Flexibility to handle multiple tasks and deadline pressures. Quality Assurance: Skills to work efficiently and effectively and strive to do so in all aspects of position. Some of medical/scientific terminology is needed primary knowledge of the Diabetes and islet transplantation is desirable. Working knowledge of Microsoft Office including Word Intermediate Excel PowerPoint Advance and Access and Reference Manager. Team player with excellent communication skills Demonstrated ability to learn and work independently and effectively by following SOPs Excellent interpersonal organizational skills detail oriented personality Is knowledgeable and compliant in all hospital State and Federal regulatory requirements including hospital policy and procedures (where applicable to the performance of the job) Joint Commission on Accreditation of Healthcare Organizations (JCAHO) and Health Insurance Portability and Accountability Act of 1996 (HIPAA) WORKING CONDITIONS: Duties will be performed in both a specialized Islet Isolation cGMP laboratory and a standard research laboratory Work will be conducted over a fortyhour workweek with scheduling flexibility required 25 to 40 of time will be evening and/or weekend hours SUPERVISORY RESPONSIBILITY: FISCAL RESPONSIBILITY: Inventory (supplies reagents animals) procurement and management within assigned budget
Required Experience:
IC
Employment Type
Full-Time
Key Skills
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