Upstream Process Development Intern

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibodybased technologies. Our team of350 dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer.Our products and platforms have attracted multiple partnerships with leading pharmaceuticaland biotechnologycompanies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics corporate culture promotes an atmosphere of innovation open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

We are seeking a highly motivated individual to join the Cell Culture Sciences group as an intern. This position will focus on the use of Ambr 15 (automated microbioreactor system) and REBEL (for spent media analysis) for use in fedbatch and perfusion recombinant protein production cell culture processes. The intern project will have 3 phases and provide an indepth experience of upstream process development.

Responsibilities and Job Duties

• Learn the basics of upstream process development. Including aseptic cell culture in shake flasks and bioreactors bioreactor setup and operation of highthroughput or benchscale disposable bioreactors cell growth monitoring and metabolite analysis.
• Collaborate with CCS team members to create execute and analyze experiments relevant to the intern project.
  • Phase 1: Implement scaledown perfusion process at Ambr 15 scale.
  • Phase 2: Experimentally optimize a platform process using spent media analysis and spiking studies. Additionally define the max/min amino acid levels for that process.
  • Phase 3: Increase efficiency of data processing and reporting inside electronic lab notebook.
• Present results and findings to CCS group and the Biopharmaceutical Development Department.

Minimum Qualifications

Education Certifications & Experience

Currently pursuing or recently completed a Bachelors degree or higher in a related science or engineering field.

Knowledge Skills and Abilities

• Basic laboratory skills and/or research experience such as: lab notebook recording analysis and

interpretation of data and safe lab practices.

• Knowledge of Microsoft Office or similar applications.
• Detailoriented reliable curiositydriven and able to perform handson work in the laboratory.
• Ability to work well in a fastpaced team environment.

Preferred Qualifications

• Cell Biology and/or cell culturing.
• Experience with statistics and/or JMP statistical software.

Additional Information

The hourly rate of pay for this position is $21.50 (Undergraduates) and $27.00 (Graduates). For nonexempt roles and according to applicable regulations there may be the possibility for overtime pay. Eligible intern employees may participate in the 401(k) plan with employer match and may receive the company holiday benefit if the holiday falls on a regularly scheduled workday. An intern will accrue one hour of sick leave for every 30 hours of working time. Interns are responsible for their own travel housing and living expenses.

The pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or calland/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled

We do notaccept nonsolicited resumes or candidate submittals from search/recruiting agencies.

Required Experience:

Intern