Senior Lead Computational Chemist
Senior Lead Computational Chemist
Posted on :
06-04-2025
Employer Active
1 Vacancy
Job Alert
You will be updated with latest job alerts via emailValid email field required
Send jobs
Share
Send me jobs like this
Job Alert
You will be updated with latest job alerts via emailValid email field required
Send jobs
Job Description
Background
Sygnature Discovery is a worldleading integrated drug discovery Contract Research Organisation based in the UK and Canada with its headquarters in Nottingham and additional facilities in Alderley Park Macclesfield Glasgow Montreal and Quebec City. Its staff of over 1000 includes 900 scientists partners with global pharma biotech and NFP organisations.
Since 2004 Sygnature Discovery has delivered over 40 novel preclinical and 22 clinical compounds with its scientists named on over 170 patents. Therapeutic areas of expertise include oncology inflammation and immunology neuroscience metabolic diseases infectious diseases fibrotic diseases and more.To find out more please visitwww.sygnaturediscovery.
Job purpose
An exciting opportunity has arisen for an experienced Senior or Lead Computational Chemist to join our Computational Chemistry group in either Alderley Park (UK) or Montreal (Canada). This is a hybrid role with an expectation to be in the office 3 4 times per week.
Our Computational Chemists play a pivotal role in driving cuttingedge research utilising the latest scientific software and cloudbased technology to solve complex challenges for clients worldwide.
As an experienced Computational Chemist you will bring broad expertise in drug discovery and compound design. This is a projectdriven role and you will be able to demonstrate your experience having worked on numerous drug discovery projects across multiple target families. This might include virtual screening and lead identification hittolead and lead optimisation projects. While experience in fragmentbased design projects is desirable it is not essential.
This is an incredible opportunity to join a worldleading CRO where you will collaborate on highimpact projects for toptier clients while advancing your career in a dynamic and innovative environment.
Main duties and responsibilities:
- Work on integrated drug discovery projects with some of the most highprofile global biotech and pharma companies.
- Chance to train and develop expertise using the latest AI/ML software.
- Learn about and apply new and emerging free energy methods on project datasets.
- Be involved with a range of new modalities such as PROTACs molecular glues macrocycles and other beyondruleof5 compounds.
- Develop drug discovery knowledge by formal training and project experience.
- Be part of an expanding group at the forefront of applying new software and techniques to drug discovery projects.
Skills and experience:
- You will have a PhD in computational chemistry or a related discipline.
- You will have worked on structurebased design projects and be familiar with this approach to optimise ligand binding.
- You will have experience of ligandbased design including development of ML or QSAR models. This would include core/fragment replacement work and focussed library design.
- Familiarity with SAR analysis of project data sets and calculation of ADME/Tox relevant properties.
- You will have carried out virtual screening either using protein Xray structures or a ligandbased method.
- Protein sequence analysis and homology modelling experience of multiple sequence alignment and homology modelling across numerous protein classes including GPCRs would be an advantage.
- Familiarity with data pipelining tools and an ability to script in python is preferred.
Benefits
Here at Sygnature Discovery we take pride in offering an excellent training and benefits package. As a valued employee you will be entitled to:
25 days annual leave (rising with service) plus bank holidays and buy/sell scheme
Private Medical Insurance
Life Insurance
Employee Assistance Programme and mental health first aiders
Enhanced Family Friendly Policies
Sygnature Group Pension Scheme
1 paid volunteer day per year
A host of flexible benefits to support your wellbeing and lifestyle
Why Sygnature Discovery
At Sygnature Discovery we embody excellence in everything we do. From pioneering research to groundbreaking discoveries we set the standard for scientific innovation. But its collaboration that truly defines us. Across continents and disciplines we unite to solve complex challenges driven by a shared passion for improving lives worldwide.
We understand the importance of creating a work environment that empowers you to thrive. Thats why we have fostered a culture of collaboration and support providing pathways for both professional and personal development. This includes a diverse range of bespoke training and development designed to accelerate both your personal and career growth.
We are committed to fostering diversity and inclusion throughout our organisation. We encourage applications from individuals of all backgrounds ethnicity gender identity sexual orientation disability neurodiversity age family or parental status beliefs nationalities and religions. We strive to cultivate an inclusive environment where all our colleagues feel empowered to bring their true selves to work.
If youre interested in joining a company that places people at the heart of its business please submit your application as soon as possible as we will be interviewing on an ongoing basis.
If you have any questions or need further information please contact the Talent Acquisition team at.Please do not submit your application to this email address.
For more information on life at Sygnature Discovery visitwww.sygnaturediscovery/careers
Required Experience:
Senior IC
Employment Type
Full-Time
Key Skills
Report This Job
Disclaimer: Drjobpro.com is only a platform that connects job seekers and employers. Applicants are advised to conduct their own independent research into the credentials of the prospective employer.We always make certain that our clients do not endorse any request for money payments, thus we advise against sharing any personal or bank-related information with any third party. If you suspect fraud or malpractice, please contact us via contact us page.
