Senior Research Associate

span idspandescdivAbout Evrys Biobr divdivThis is an opportunity to join a small entrepreneurial and wellfunded biotech company Building on research breakthroughs from an internationally renowned scientific team Evrys research platform has enabled us to discover new antiviral drugs with a different mechanistic approach that will change the way infection is treated from one virus at a time to broadspectrum therapies simultaneously effective against different viruses without the emergence of drug resistance Evrys Bio antivirals target special human proteins known as sirtuins enhancing their natural ability to fight powerful infections  The company is funded by private investors and by multimilliondollar government grants and contracts to develop therapies addressing infection control pandemic preparedness and biodefensebr divdiv br divdivWe are searching for an experienced Senior Research Associate to join the team The successful candidate will have a Master s degree in Virology Immunology Microbiology or related biological sciences or a Bachelor s degree with equivalent experience and   years drug discovery experience The candidate is expected to  be highly motivated and hardworking and has advanced laboratory skills in cellular and molecular biologybr divdivbr divdivKey Responsibilities br divdivPropagation of BSL level viruses and cell lines for evaluation of candidate drugsbr divdiv Standard analyses of cell growth properties and viral replicationbr divdiv Molecular and cell biological analysis of both viral and cellular targets of candidate drugs including signal transduction assays of observed antiviral effectsbr divdiv Routine screening of candidate drugs in highthroughput plate format ( well)br divdiv Critical evaluation of primary data effective record keeping laboratory notebook maintenance and standard laboratory maintenancebr divdiv Present to the research team on a weekly basis and have interactions with all other Evrys team members participate in manuscript publicationbr divdivbr divspanbr span idspanreqhRequirementshdivQualifications and Skills Requirements br divdiv years of laboratory work and industry experiencebr divdiv Master s degree (or Bachelor s degree with equivalent experience) in Virology Immunology Microbiology or related biological sciencesbr divdiv Efficient tissue culture techniques of mammalian cell linesbr divdiv Experience with DNA manipulation cloning transfection lentiviral transductionbr divdiv BSL tissue culture respiratory viruses DNARNA viruses virus propagation and titrationbr divdiv Protein expression purificationbr divdiv DNA and RNA handling and analyses (eg nucleic acid extraction qPCR)br divdiv Standard protein analyses techniques (eg Western blot Immunofluorescence assay)br divdiv Standard bacterial genetics is a plus (eg plasmid preps molecular cloning)br divdiv Previous experience with Seahorse cell metabolic analysis andor lipidomics is a plusbr divdiv Efficient time management and excellent multitasking skillsbr divdiv Proficiency in spoken and written English as well as relevant computer skills (eg Excel PowerPoint and Word)br divspanbr Qualifications and Skills Requirements: 7+ years of laboratory work and industry experience Master s degree (or Bachelor s degree with equivalent experience) in Virology, Immunology, Microbiology or related biological sciences Efficient tissue culture techniques of mammalian cell lines Experience with DNA manipulation, cloning, transfection, lentiviral transduction BSL2+ tissue culture, respiratory viruses, DNA/RNA viruses, virus propagation and titration Protein expression, purification DNA and RNA handling and analyses (e.g., nucleic acid extraction, qPCR) Standard protein analyses techniques (e.g., Western blot, Immunofluorescence assay) Standard bacterial genetics is a plus (e.g., plasmid preps, molecular cloning) Previous experience with Seahorse cell metabolic analysis and/or lipidomics is a plus Efficient time management and excellent multitasking skills Proficiency in spoken and written English, as well as relevant computer skills (e.g. Excel, PowerPoint, and Word)