Senior Research Associate - Discovery and Research - Ophthalmology

Our client, Tenpoint Therapeutics Ltd, a company founded in 2020 is dedicated to the creation and development of novel, innovative cell-based / regenerative therapies for the treatment of ocular diseases. Tenpoint is committed to creating an inclusive, diverse, supportive work environment and fosters the personal / professional growth of their employees. They will be establishing one of their laboratories in Allschwil, Switzerland and will be building-up the research team to contribute to the development of growing Tenpoint's portfolio programs, giving the successful candidate exposure to all stages of drug discovery. Working Location: Allschw

Tasks

• Support all research activities and contribute to the development of growing Tenpoint's portfolio programs
• Cultivation of healthy and engineered human iPS/ES cells, maintenance and differentiation to retinal pigment epithelial cells (RPE), retinal organoids and co-culture of two or three cell types.
• Charactization and functional analysis of retinal organoids/RPE using fluorescence microscopy, image analysis, flow cytometry, FACS, MACS, fluorescence/luminance-plate reader, gene expression analysis, western blot & histology.
• Perform in vitro pharmacology studies, development & establishment cell-based assays to evaluate mechanisms of action.
• Work independently with minimal supervision. Plan and execute experiments, analyse, interpret, accurately document (electronic lab notebook) and communicate data in team meetings.
• Involvement in cell culture lab management and organization.

Requirements

• Completed training as a BTA/CTA/MTA/biology lab technician with work experience or BSc/MSc in Life sciences (biology, biotechnology, genetic engineering) or other relevant area.
• Background in ophthalmology and extensive experience (5 years) human iPSC/ESCs and its differentiation different ocular cell types (retinal organoids, RPE and others).
• Experience in drug discovery research/pharma/biotech & complement biology is a plus.
• Hands-on experience in assay development, co-culture of multiple cell types (example: endothelial cells), luminescence/fluorescence plate-based assays, flow cytometry, cell sorting (MACS / FACS), cryo-sectioning, immunohistochemistry, fluorescence microscopy, image analysis, gene and protein analysis.
• Knowledgeable with various genetic perturbation methods (gene editing, RNAi, viral transduction etc.) and validation assays.
• Team-oriented, responsible and reliable personality with a positive can-do attitude.
• Willingness to learn a variety of new techniques and technologies and flexible to adapt to rapidly changing priorities and deadlines.

Benefits

• A stimulating and challenging position in a fast-paced environment
• Independent work in a highly motivated team
• An open, dynamic, collaborative and multi-disciplinary environment
• Attractive employment conditions, competitive remuneration and social benefits

If you are interested in this exciting challenge, please apply online to Mr Kelaja Wick. On our homepage you will also find other exciting positions and more information about the application process. We look forward to meeting you in person soon. Discretion is our capital