Instrument Chemist Senior Analyst Executive – Instrumentation

Position Title: Instrument Chemist / Senior Analyst / Executive Instrumentation

Job Overview:

An Instrument Chemist with 2 to 3 years of experience specializes in the routine operation basic calibration and troubleshooting of high-end analytical equipment. This role typically operates within Quality Control (QC) Analytical Research and Development (AR&D) or commercial testing laboratories (Pharma Food Environmental Agrochemical).

1. Experience Required: 2 to 3 years of hands-on laboratory experience
2. Salary: Up to 3.6 LPA
3. Location: Head Office Sindhubhavan Ahmedabad
4. Core Focus: Advanced chromatographic and mass spectrometric analysis (GC GC-MS GC-MS/MS HPLC)
5. Education: Masters Degree in Chemistry Analytical Chemistry or Pharmaceutical Sciences

Key Responsibilities

1. Instrument Operation & Testing

1. Execute sample analysis using Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC).
2. Perform trace-level quantification using hyphenated techniques like GC-MS and GC-MS/MS for residual solvents pesticides or impurities.
3. Prepare samples using techniques like liquid-liquid extraction Solid-Phase Extraction (SPE) and headspace sampling.

2. Calibration & Maintenance

1. Conduct routine calibration of HPLC and GC systems to ensure instrument compliance.
2. Perform basic maintenance including replacing GC septa liners syringe needles HPLC columns guard columns and mobile phase filters.
3. Execute system suitability tests (SST) prior to sample batch execution to verify instrument performance. 1 2 3 4

3. Data Analysis & Documentation

1. Process raw chromatographic data using software like Empower Chromeleon or LabSolutions.
2. Review peak integrations interpret mass spectra fragments and calculate final concentrations against standards.
3. Maintain meticulous documentation of raw data logbooks and analyst worksheets in line with Good Laboratory Practices (GLP).

4. Compliance & Troubleshooting

1. Investigate Out of Specification (OOS) or Out of Trend (OOT) results under senior supervision.
2. Identify system errors like baseline drift pressure fluctuations or ghost peaks and implement initial corrective actions.
3. Adhere to safety data integrity and regulatory protocols (such as USFDA MHRA or NABL/ISO 17025 depending on the industry).

Required Technical Skills

1. HPLC/GC: Proficiency in standard isocratic and gradient runs injection mechanisms and standard detectors (UV-Vis PDA FID ECD).
2. Mass Spectrometry: Understanding of electron ionization (EI) single quad (MS) scanning and triple quadrupole (MS/MS) Multiple Reaction Monitoring (MRM) modes.
3. Software: Experience with chromatography data systems (CDS) and basic mass spec tuning interfaces.
4. Method Verification: Competence in assisting senior scientists with method validation and verification protocols.

Soft Skills & Behavioural Competencies

1. Strong attention to detail
2. Analytical thinking and problem-solving
3. Clear communication for cross-functional collaboration
4. Time management to handle high sample throughputs

*Shruti Patel*

White Force Outsourcing Pvt. Ltd.

Required Skills:

HPLC/GC Mass Spectrometry Software Method Verification: