Senior Scientist, Stem Cell-Derived Tissue Models( Contract)

Career Category

Job Description

Join Amgens Mission of Serving Patients

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer heart disease inflammatory conditions rare diseases and obesity and obesity-related conditions. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do

Lets do this. Lets change the this vital role you will join the Predictive Biology team to develop and validate biologically relevant models of human tissue using induced pluripotent stem cell (iPSC) or primary human tissue. A key focus will be validating tissue architecture cellular composition differentiation state maturation and functional relevance to ensure models are suitable for discovery and translational research.

Key Responsibilities

• Develop human stem cell-derived models that represent tissue biology and enable disease-versus-normal comparisons.
• Differentiate stem cells into diverse tissue-relevant cell types.
• Build complex model systems including organoids assembloids co-cultures matrix-supported cultures or other multicellular tissue-like systems.
• Optimize culture conditions media composition growth factor cues extracellular matrix conditions differentiation timing and co-culture parameters.
• Validate model fidelity using readouts of cell identity tissue architecture maturation and tissue-specific function.
• Document protocols experimental designs model validation data and decision criteria in a clear and reproducible manner.
• Communicate results limitations and technical risks to cross-functional teams through written reports and oral presentations.

What we expect of you

We are all different yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a professional with these qualifications.

Basic Qualifications

• PhD in a related discipline with 2 years of experience
• MSc with 5 years of experience.
• BSc with 8 years of experience.

Preferred Qualifications

• PhD with 2 years postdoctoral and/or industry experience in stem cell biology developmental biology tissue engineering cell biology bioengineering molecular biology organoid biology or a related discipline.
• Hands-on experience culturing and differentiating stem cells across relevant model systems
• Experience validating tissue architecture using methods such as immunostaining confocal microscopy flow cytometry high-content imaging or functional assays.
• Experience optimizing media growth factors extracellular matrix conditions differentiation timing and co-culture conditions for multicellular model systems.
• Familiarity with adult stem cell-derived organoids Lgr5-positive stem cell biology niche-factor-dependent epithelial systems normal organoids or patient-derived organoid platforms is preferred but not required.
• Demonstrated scientific productivity and technical credibility through peer-reviewed publications and patents
• Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.

What you can expect of us
As we work to develop treatments that take care of others we also work to care for our teammates professional and personal growth and well-being.

Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click HERE for more details.

The salary range for this position in Canada is $115503 - $156269 CAD.

In addition to the base salary Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Apply now and make a lasting impact with the Amgen team.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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