Research Technician IIIII

Union: Non-Union
Number of Vacancies: 1
New or Replacement Position: New
Site: Princess Margaret Cancer Centre
Department: Research
Reports to: Principal Investigator
Salary Range: $31.03 - $46.84 hourly
Hours: 37.5 hours a week
Shifts: Monday - Friday
Status: Temporary Full-Time (1 year contract)
Closing Date: August 16 2026

Position Summary

Our lab is a multidisciplinary research program based at the Princess Margaret Cancer Centre University Health Network and closely integrated with the Structural Genomics Consortium. We operate at the intersection of clinical oncology experimental biology and functional genomics with a focus on understanding chromatin architecture epigenetic regulation and tumor heterogeneity in cancer.

The lab uses 3D genome mapping chromatin profiling next-generation sequencing patient-derived models and multi-omic approaches to identify regulatory mechanisms that may inform precision oncology strategies biomarker discovery and epigenome-informed therapeutic approaches.

We are seeking a highly motivated Research Technician with strong wet-lab experience to support and execute experimental projects in cancer epigenomics and 3D genome biology. The successful candidate will contribute to projects involving chromatin conformation assays functional epigenomics next-generation sequencing library preparation and patient-derived model systems.

This position is ideal for a candidate with hands-on experience in molecular biology genomics epigenomics and cancer biology who is interested in working in a collaborative translational research environment.

Duties

• Perform and optimize molecular biology and functional genomics experiments related to cancer epigenomics.
• Carry out chromatin and sequencing-based assays including Hi-C HiChIP ATAC-seq CUT&RUN CUT&Tag and related methods as applicable.
• Prepare next-generation sequencing libraries across multiple assay types.
• Work with patient-derived cancer models including organoids or related culture systems.
• Support sample processing quality control library preparation and coordination of sequencing submissions.
• Maintain accurate experimental records protocols sample inventories and laboratory documentation.
• Assist with troubleshooting and optimization of complex wet-lab protocols.
• Coordinate with computational scientists and other team members to support data generation interpretation and project progress.
• Contribute to the generation of figures summaries and experimental documentation for manuscripts grants presentations and reports.
• Assist with ordering reagent preparation equipment maintenance and general laboratory organization.
• Support training of junior lab members or students in established protocols as appropriate.
• Contribute to a collaborative rigorous and well-organized lab environment.

Qualifications :

• At minimum Bachelors degree in Molecular Biology Cancer Biology Genetics Genomics Biochemistry Cell Biology or a related field required 
  • Masters degree an asset
• Minimum of 3 years of relevant wet-lab research experience required 
• Strong hands-on experience with molecular biology and genomics techniques.
• Experience with next-generation sequencing library preparation.
• Experience with chromatin-based or epigenomics assays such as ATAC-seq CUT&RUN CUT&Tag Hi-C HiChIP Capture-C or related methods.
• Experience with patient-derived organoid culture or other cancer model systems.
• Ability to follow optimize and troubleshoot complex experimental protocols.
• Strong organizational skills and careful attention to detail.
• Ability to maintain clear and accurate experimental records.
• Excellent communication skills and fluency in English written and spoken.
• Ability to work effectively in a collaborative multidisciplinary research environment.
• Ability to manage multiple experimental tasks and timelines.
• Direct experience with 3D genome assays such as Hi-C HiChIP Capture-C Micro-C or related methods an asset
• Experience with single-cell or spatial genomics workflows an asset 
• Experience with low-input or challenging clinical/research samples an asset
• Basic familiarity with genomic data analysis concepts and tools including R Python command-line environments or sequencing QC metrics an asset
• Experience working in a translational cancer research environment an asset
• Prior experience contributing to manuscripts reports or grant-related experimental summaries an asset

Additional Information :

Why join UHN

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN. 

• Competitive offer packages  
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP access to Transit and UHN shuttle service 
• A flexible work environment  
• Opportunities for development and promotions within a large organization 
• Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts on-site gyms etc.) 

Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration. 

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly. At University Health Network (UHN) artificial intelligence technologies may be used to assist in the screening assessment and selection of candidates for this position.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest however only those selected for further consideration will be contacted.

Remote Work :

No

Employment Type :

Intern