Sr. Scientist, Translational Medicine

Life at BMS

At RayzeBio every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb RayzeBio blends the nimble pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here youll join a multidisciplinary team where your ideas are valued your expertise is amplified and collaboration is at the heart of everything we do. From day one expect to make an immediate impacton our science on our teams and most importantly on patients. Learn more about RayzeBio: is a dynamic biotechnology company headquartered in San Diego CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio will operate as a standalone entity within the BMS organization maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset RYZ101 is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) as well as earlier stage testing for patients with small cell lung cancer (SCLC). Led by a successful and experienced entrepreneurial team RayzeBio aims to be the global leader in radiopharmaceuticals.

Job Description

As a Senior Scientist Translational Medicine supports clinical biomarker strategy for our oncology pipeline. This is an operationally focused hands-on role for a scientist who has already worked directly on oncology clinical studies and understands what it takes to get biomarker samples from protocol design through data delivery. The successful candidate will partner closely with Clinical Development Clinical Operations Biostatistics Regulatory and Data Management to ensure biomarker sample collection central lab and CRO/vendor oversight and analytical assay execution are planned and delivered to the highest scientific and quality standards across one or more oncology clinical programs.

This role is best suited to a scientist with a strong foundation in clinical biomarker operations who is ready to grow into broader translational strategy leadership. The Senior Scientist will work under the guidance of the Translational Medicine Lead while independently owning day-to-day biomarker execution for assigned studies. As they gain experience the role expands to include progressive ownership of biomarker strategy as well as driving scientific data interpretation and actionable recommendations. The position will require an ability to work effectively in interdisciplinary team settings. The role requires an ability and willingness to work with radioactive isotopes.

Job Responsibilities

• Essential duties and responsibilities include the following. Other duties may be assigned.
• Serve as the primary biomarker/translational medicine representative on clinical study teams for oncology trials.
• Support end-to-end management of biomarker sample logistics chain-of-custody inventory tracking reconciliation and deviation resolution in collaboration with Clinical Operations and clinical sites.
• Provide scientific review of biomarker components in protocols ICFs regulatory documents laboratory manuals and sample collection tables/kits to ensure biomarker objectives sample types collection procedures and logistics are scientifically sound and operationally feasible in alignment with GCP/GCLP.
• Partner with Data Management and Biostatistics on eCRF/biomarker data specifications data transfer agreements and data reconciliation.
• Oversee assay selection tech transfer and cross-validation for exploratory and clinical endpoints (IHC immunoassays NGS qPCR). Evaluate vendor assay readiness by reviewing validation plans reports and performance data to ensure fitness-for-purpose.
• Manage CROs and specialty testing vendors from qualification and SOW/contract review to ongoing performance monitoring. Troubleshoot logistical/technical issues oversee assay transfers and act as the primary scientific point of contact.
• Collaborate with Translational Science and BMS teams on assay selection cross-validation and platform transfer for exploratory biomarker endpoints.
• Support development and maintenance of SOPs best practices and tracking tools for biomarker sample and vendor management.
• Communicate biomarker sample status testing timelines and data readiness to study teams and management; escalate risks proactively.
• Contribute to interpretation of biomarker data in the context of efficacy safety and patient selection to inform program decisions.
• Uses AI tools to enhance individual productivity and quality of work

Education and Experience

• Ph.D. in a relevant scientific discipline (e.g. oncology molecular biology immunology cancer biology) with minimum of 2 years of direct experience supporting oncology clinical studies within a pharmaceutical biotechnology or CRO setting.
• Hands-on experience with clinical study protocol and ICF review biomarker sample collection procedures and end-to-end sample management (collection tracking shipment storage reconciliation).
• Demonstrated experience working cross-functionally with Clinical Operations Clinical Science Biostatistics Data Management and Regulatory/QA teams.
• Direct experience working with central laboratories and external CRO/testing laboratories including vendor communication and issue resolution.
• Working familiarity with analytical assay validation/qualification principles for the following: IHC immunoassay platforms and sequencing-based (NGS/qPCR) technologies.
• Experience contributing to or supporting the selection qualification and oversight of external vendors.
• Strong organizational project management and communication skills; ability to manage multiple studies/priorities in a matrixed environment.
• Working knowledge of GCP GCLP and applicable regulatory requirements governing clinical biomarker sample handling and testing.

Preferred Qualifications

• Experience working on clinical studies involving radiopharmaceutical therapy (RPT)/radioligand therapy (RLT) programs.

• Prior experience authoring or reviewing translational/biomarker sections of clinical protocols laboratory manuals or regulatory submissions.

• Familiarity with electronic data capture and sample tracking systems.

• Experience supporting assay transfer cross-validation or bridging studies between internal and external laboratories.

• Prior involvement in vendor audits or supplier quality assessments.

• Ability to work collaboratively with clinicians researchers bioinformaticians and other stakeholders to integrate diverse perspectives and advance translational research goals.

• Excellent written and oral communication and presentation skills and ability to work in a fast-paced dynamic and collaborative environment.

• Strong interpersonal organizational and communication skills.

• Ability to work with radioisotopes with strict adherence to radiation safety protocols.

We hire for skills and capabilities not just credentials if this role excites you but doesnt perfectly match your resume we encourage you to apply anyway.

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully carefully considering the nature of the role required skills work location schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors and individual team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect you may be eligible to participate in our comprehensive benefit plans including wellbeing support retirement and financial protection benefits and insurance offerings (medical dental vision life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO) which provides paid time off without a set accrual limit subject to manager approval along with 11 paid company holidays each year.

Non-exempt employees RayzeBio employees and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval) 11 paid company holidays and 3 optional holidays.

Depending on eligibility employees may also have access to additional time-off benefits including paid sick leave up to two paid volunteer days per year summer hours flexibility and leaves of absence for medical personal parental caregiver bereavement or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Years Day.

U.S.-based job seekers can explore full benefit offerings at and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplaceaccommodations/adjustmentsand ongoing support in their roles. Applicants can request a reasonable workplaceaccommodation/adjustmentprior to accepting a job offer. If you require reasonableaccommodations/adjustmentsin completing this application or in any part of the recruitment process direct your inquiries to. Visit access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider qualified applicants with arrest and conviction records pursuant to applicable laws in your area.

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