Sr. Research Associate Gene Therapy

The Role

Senior Research Associate As a hands-on molecular biology expert you will play a key role in advancing Dynos animal studies to identify and develop cutting-edge muscle AAV-based capsids. You will process and analyze tissues from in vivo studies support histology workflows and conduct in vitro experiments to characterize leading capsids and capsid libraries. Working closely with Research Associates Scientists and Computational Biologists you will help the Muscle team generate high-quality data that shapes the future of gene therapy.

Job Type: Full Time

Location: Watertown

How You Will Contribute

As a Senior Research Associate you will provide hands-on experimental support across tissue processing molecular measurements histology and in vitro characterization. You will work alongside a team of talented scientists and contribute to a diverse range of projects. Your role will require you to optimize workflows troubleshoot problems and ensure successful project outcomes by aligning with team goals.

At Dyno every role is mission-driven. Whether in science engineering operations or business each AAViator contributes to solving some of the most complex challenges in genetic medicine.

Responsibilities:

• Sample inventory and dissection of tissues (mammalian cells non-human primate and mouse tissues).
• Extract purify and enrich nucleic acids from mammalian cells and tissues.
• Run quantification assays on purified nucleic acids (e.g. qPCR RT-qPCR).
• Prepare next-generation sequencing libraries (amplicon sequencing) and perform associated QC steps.
• Support histology workflows including tissue preparation sectioning staining imaging and analysis.
• Maintain mammalian cell cultures and execute cell-based experiments to characterize leading muscle capsids and capsid libraries.
• Analyze experimental data identify technical issues and recommend appropriate next steps in collaboration with project leads.
• Maintain detailed and accurate records of samples experimental procedures and results using Dynos electronic laboratory notebook and LIMS systems.
• Communicate findings clearly and collaborate across experimental and computational teams to achieve project goals.
• Adhere to lab protocols and safety regulations to ensure a safe working environment.
• Work with urgency and adaptability balancing innovation with execution.
• Collaborate cross-functionally leveraging Dynos high-trust high-impact culture to drive results.

Basic qualifications

• BS or MS in biology biochemistry biomedical engineering or related fields.
• At least 3 years of full time post graduate hands-on wet lab experience.
• Experience in DNA/RNA purification and analysis protocols (qPCR RT-qPCR etc.).
• Experience handling mammalian tissues or other complex biological samples.
• Ability to execute complex protocols with high accuracy consistency and attention to detail
• Ability to organize and track large sample sets across multiple concurrent studies and workflows.
• Strong experimental documentation and data-management practices.
• Ability to analyze data identify technical problems and contribute to decisions about experimental next steps.
• Willingness to push the boundaries of work through the use of AI.
• Alignment with Dynos core values - We seek individuals who step up when things get tough recalibrate when priorities shift and thrive in a high-expectation environment.
• A proactive problem-solving mindset - you dont just identify challenges; you find solutions.

Preferred qualifications

• Experience with AAV biology gene therapy viral vectors or drug-delivery technologies.
• Experience with next-generation sequencing library preparation.
• Experience processing animal tissues for molecular measurements including vector genome mRNA or protein analysis.
• Experience with histology workflows including tissue preparation sectioning staining imaging or quantitative analysis.
• Familiarity with ELN-LIMS data management software (e.g. Benchling).

The Company

At Dyno Therapeutics we are a high-energy high-impact team on a mission to build high-performance genetic technologies that transform patient lives. Our team unites world-class molecular biologists protein engineers software developers data scientists and machine learning expertsall working together at the intersection of AI and genetic medicine.

Our culture is defined by three core values that guide everything we do:

• One Mission: Everything we do is for the mission. We are a cohesive and motivated team thinking ahead and supporting one another to overcome challenges.
• Proactive Responsibility: We take action inject energy into our work and hold ourselves accountable for delivering results.
• Reaching for Excellence: We constantly strive for excellence fueled by curiosity adaptability and the courage to speak hard truths in pursuit of success.

These values are more than wordsthey drive our actions and decisions. Our greatest strength isnt technologyits our work ethic. More than just technologists were a team of relentlessly resourceful problem-solvers: with an unshakable drive we generate breakthroughs at the intersection of AI and genetic medicine.

What Youll Give:

• Bring an unstoppable work ethic stepping up when things get tough and adapting as priorities shift.
• Embrace challenges as opportunities finding solutions where none exist and driving innovation forward.
• Operate with urgency responsibility and resilience because this mission demands the best from us.

What Youll Get:

• Competitive compensation & equityyour contributions drive results and we pay accordingly.
• Mission-aligned high-trust environmentwe succeed together supporting each other through challenges.
• A career-defining experiencework at the forefront of AI-driven genetic medicine tackling problems that reshape healthcare.

If youre ready to push boundaries build the future and thrive in a fast-moving high-impact environmentwed love to hear from you.

At Dyno we believe in transparent and equitable compensation practices.

Base Salary Range: $96172.08 - $116236.54/year

This reflects the typical offer range for this role based on experience role scope and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidates experience interview performance and expected impact.

This role is eligible for:

• Annual performance-based bonus
• Stock options
• Comprehensive medical dental and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-campus gym membership onsite lunch commuter support and company provided laptop

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

Equal Employment Opportunity (EEO) Statement

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race religion color national origin gender sexual orientation age marital status veteran status or disability status.

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