Senior Staff Engineer, Software

PacBio (NASDAQ: PACB) is a premier life science technology company that designs develops and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.

Position Summary:
The Senior Staff Software Engineer is responsible for designing developing and delivering business-critical instrument control software for next-generation sequencing platforms. This is a highly visible cross-functional role that works closely with mechanical electrical firmware and systems engineering teams at PacBio. This role is ideal for a deeply technical engineer who thrives on solving complex system-level challenges and driving high-impact software solutions at the intersection of hardware and software.

Responsibilities:

• Own and deliver business-critical instrument control software spanning multiple subsystems directly impacting instrument performance reliability and customer experience
• Drive technical design and implementation for complex high-risk areas independently defining approach and managing technical risk
• Collaborate cross-functionally with mechanical electrical firmware and systems teams to ensure robust hardware-software integration and clear requirements
• Identify and resolve systemic issues in performance reliability and scalability including proactively addressing technical debt
• Lead design and code reviews while contributing hands-on development in C#/.NET ensuring high-quality maintainable software
• Influence system architecture and technical direction and mentor engineers to elevate team-wide engineering standards

Required Qualifications:

• Bachelors degree in Computer Science Engineering or a related discipline
• 10 years of software engineering experience
• Deep expertise in C#/.NET and proficiency in Python
• Strong experience with real-time or embedded systems and hardware-software integration
• Experience working with hardware systems such as robotics optical systems environmental sensors or motion control
• Strong proficiency with Linux environments
• Solid understanding of software architecture design principles and best practices
• Experience developing instrument control software user interfaces and system-level integrations
• Experience designing and implementing APIs (e.g. RESTful services)
• Demonstrated ability to independently drive complex technical projects from concept to production
• Excellent interpersonal written and verbal communication skills

Preferred Experience:

• Experience developing scientific instrumentation
• Masters degree or higher in a technical field
• Experience working with firmware and low-level system interactions (e.g. FPGA interfaces)
• Experience with Agile software development methodologies
• Experience with DevOps practices CI/CD pipelines and automated testing frameworks
• Experience in life sciences biotech medical devices or other regulated environments

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race sex color religion national origin protected veteran status or on the basis of disability gender identity and sexual orientation.

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All qualified applicants will receive consideration for employment without regard to race sex color religion national origin protected veteran status or on the basis of disability gender identity and sexual orientation.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying you may contact us at or for assistance.

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