Senior Scientist, Translational PKPD

Job Description

The department of Pharmacokinetics Dynamics Metabolism & Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior Scientist is a skilled mathematical modeler and scientist who designs and executes analyses with supervision guiding drug discovery strategy with a focus on biologics protein therapeutics and peptides.

The Translational PK/PD Senior Scientist will:

• Serve as PK/PD modeler in cross-functional teams to make model-informed decisions about drug discovery modality selection and dose prediction across therapeutic areas;

• Integrate in vitro and in vivo data to build PKPD PBPK quantitative systems pharmacology (QSP) or other mechanistic modeling platforms of drug disposition and pharmacology to support forward/reverse translation for both established and novel therapeutic targets;

• Collaborate across our PDMB and broader Discovery / Translational organization to design experimental studies and modeling plans to identify and optimize drug candidates;

• Collaborate in the design of automated workflows for implementing modeling platforms to inform human PK/PD and dose projections;

• With guidance from experienced modelers continue to build expertise and leadership skills in translational modeling and drug discovery.

In addition to the responsibilities described above the Senior Scientist will demonstrate strong leadership and communication skills drawing upon their training and experience to enable model-informed drug discovery.

NOTE: This role is available in South San Francisco CA West Point PA or Boston MA based on candidate preference.

QUALIFICATIONS:

Education:

• Masters (with 3 years) PharmD (with 1 year) or Ph.D. in pharmacokinetics/pharmacodynamics mathematics applied mathematics systems biology computational biology chemical/biomedical engineering statistics/biostatistics or related discipline and experience with increasing responsibility and independence in drug discovery / development within industry academia regulatory or non-profit settings

Required Experience and Skills:

• Experience performing hands-on translational PKPD modeling using standard modeling software (e.g. Matlab OSP Suite Monolix R)

• Strong skills in experimental design mathematical problem solving critical data analysis/interpretation and/or statistics

Preferred Experience and Skills:

• Experience using mathematical modeling to inform decisions related to discovery / development of biologics protein therapeutics and/or peptides

• Demonstrated ability to work in interdisciplinary teams and in collaborative problem solving

• Expertise in developing novel PKPD PBPK QSP or related mechanistic modeling approaches

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The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

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