Senior Scientist, Discovery Technologies

What ifyou could join an organization that creates resources and builds life sciences companies that invent breakthrough technologiesin order totransform health care and sustainability

Flagship Labs 129 (FL129) is an early-stage biotechnology startup with an ambitious and exciting mission:to develop a technology tofacilitatethe data generation necessary for training the next generation of generative chemistry models to unlock the future of small molecule drug discovery. FL129 is developing a revolutionary approach to this challenge and is recruiting a team of top-tier scientists to build this powerful and first-in-category platform. This is a unique opportunity to be one of the first employees of a biotech startup that combines an innovative mindset with the resources andknow-howof Flagship Pioneering.

Position Summary:

We are seeking a motivated and highly collaborative Senior Scientist to join FL129s growing team of experimental and computational scientists to build a novel platform technology. The successful candidate will have strong track record of scientific and technical innovation in molecular biology and small molecule screening including experience adapting screens to cell- or surface-displayed protein targets. Additional experience with or exposure to yeast surface display single-cell or genomics methods and cheminformatics are preferred. The ideal teammate will be highly adaptable have strong organizational and communication skills and will thrive in a highly collaborative and multidisciplinary environment.

Key Responsibilities:

• Technology development aligned with FL129s core strategic goals. This role is among the first hires andwerelooking for someone who thinks critically and will influence the companys scientific direction.

• Design construction and experimental testing of custom target/variant libraries including binding assays against cell- or surface-displayed protein targets

• Optimizeexisting workflows andestablishbest experimental and documentation practices to enable platform excellence.

• Ensuring rapid andaccurateturnaround of data to drive achievement of key project goals.

• Translate experimental data into meaningful insights and present results at team meetings.

Preferred Qualifications:

• Ph.D. in molecular biologysystems biologychemical biology or a similar field with 5 years of industry or postdoctoral experience.

• End-to-end experience withsmall moleculescreening from library design including optimization of DNA tags for amplificationquantitationand sequencing toscreening next-gensequencing to data analysis.

• Experience managing contract research organizations (CROs).

• Nice tohave:cheminformatics experience on-DNA and off-DNA hit validation experiencewith DNA-encoded positive control and library compoundssurface display technologies droplet-based screening and/or microfluidicsand single-cell or genomics methods.

• Motivated team-player and independent force-of-nature with strong organizational and written/verbal communication skills.

What we can offer you:

• Opportunity to lay the scientific foundation of a transformative platform company as an early employee.

• Custom-tailored role to maximize impactful contributions professional growth and scientific interests.

• Weekly lunches monthly social events and community lunchroom with free snacks coffee all embedded in a vibrant community of scientists and entrepreneurs across multiple Flagship Pioneering portfolio companies.

We are seeking individuals with an entrepreneurial spiritstrong communicationskills and comfort in working in and contributing to a dynamic and cross-functional team environment. The level of the role will becommensuratewith the education and years of experience of the identified candidates.

Flagship Pioneering and our ecosystem companies arecommitted to equal employment opportunityregardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability genderidentityor Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP and FSP will not owe any referral or other fees with respect thereto

The salary range for this role is $126000 - $181500. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. FL129 currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL129s good faith estimate as of the date of publication and may be modified in the future.

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