Senior Scientist, Degrader Antibody Conjugate Cellular Pharmacology

Senior Scientist - Degrader Antibody Conjugate Cellular

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery development and commercialization of targeted protein degradation medicines the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class and coupled with unparalleled ligase expertise Nurixs dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care writing medicines next chapter with a new script to outmatch disease.

Position:

We areseeking anaccomplished scientific leaderwho willdefine and driveourin vitroscreening and pharmacological characterization capability for Degrader Antibody Conjugates (DACs). Our DAC platform pairs antibody-based targeting with our degraderexpertiseto direct protein degradation to specific cell types and this scientist willown theinvitrostrategydefining how candidate molecules move through thescreeningcascade fromprimary screening through mechanistic pharmacological characterizationofdrug candidates.

This is a hands-on leadership role for someone who has built deep expertise in the ADC and/or DAC field and wants toapply that experience in designing and runningin vitropharmacology studies into ahighly collaborative discovery organization while operating with a high degree of scientific independence. Thescientist will independentlydesign execute and analyze cellular assays that characterize DAC activity and will partner closely withdiscovery biology conjugation chemistryanalyticalbiochemistry DMPK and automation to advance candidates from early screeningthrough development depends as much on scientific vision influence and communication as on technical depth: the ideal candidate is self-driven resourceful and organized a strong strategic thinker an effective and compelling presenter and a proven leader who can align and drive teams in a matrixed setting without relying on direct authority.

Responsibilities:

• Bring rich knowledge of the preclinical drug discoveryworkflowfor ADCs/DACsto shape integrated characterization plans connectin vitropharmacology toin vivoandtranslational strategy andanticipatethe data packages needed for candidate progression.

• Design build anddrivethein vitropharmacologyand screeningframework forDACs and biologics from primary screening through mechanistic and quantitative characterization.

• Serve asa keyscientific decision-driver for DACin vitropharmacology providing sound judgment on assay strategy data interpretation and go/no-go recommendations.

• Lead and influence a matrixed cross-functional organization partnering with discovery biology conjugation chemistry analytical biochemistry DMPK andchemistryautomation to translate strategy into execution and to advance multiple programs in parallel.

• Leadthe design and execution of pharmacology studies working closely with team membersto assess the biological activity and mechanism of action oflead molecules and drug candidates.

• Develop and perform cell-based assays to characterize DAC and biologic activity includingantigen bindingtarget engagement and targeted protein degradationusingcutting-edgetechnologiesand automated workflows.

• Cultivate andmaintainmammalian celllines(experiencemanipulating cell surfaceantigensand engineeringreporter linesused to characterize DACsispreferred).

• Stay current with the latest scientific literature and industry developments in the fieldsofADCs DACs biologics and targeted protein degradation.

• Mentor and develop scientistsin a matrixed environmenttobuild team capabilities andensure compliancetobest practices.

• Communicate and champion scientific findings and strategy through clear compelling presentations to project teamsandsenior leadership;author study reports and technicaldocumentation anddrivescientific discussions thatshape projectdirection.

Qualifications:

• Ph.D. in a relevant scientific field (Biochemistry Pharmacology Biology etc.) with4 or more years of relevant post-graduate industry oracademicresearch experience or MS with8or moreyears ofrelevantindustry experience.

• Demonstrated experience designing and setting upin vitropharmacology studies and screening cascades; priorexperiencebuilding screening/assay cascades in the ADC or DAC field isstronglypreferred.

• Demonstrated leadership in a matrixed cross-functional environment with the ability to influence align anddrive teams and programs.

• Excellent communication and presentation skills witha track recordof clearly conveying complex science and recommendations to project teams and senior leadership.

• Hands-on experience with mammalian cell cultureandtheability toindependently execute analyze and report results ofquantitative cellular assaysrelevant to conjugate characterization (e.g. luminescence-based degradation viability or internalizationassays).

• Experiencewith mechanistic assays that dissect DAC activity such asantibody binding andintracellulardrug release is highly desired.

• Familiarity with automation equipment ( handlers) and automated workflows.

• Stronganalytical and problem-solving skillswith sound judgment inevaluating and interpreting experimentaldata.
• Demonstratedability to manage priorities and advance multiple projects simultaneously in a matrixed cross-functional environment.

Salary: $161900 - $173900

Location:Brisbane CA (Onsite role)

Nurix Culture and Values

• Strong teamorientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view