Senior Scientist, ADC In Vivo Pharmacology

Position Summary

Pfizer is seeking an accomplished Senior Scientist to join the In Vivo Pharmacology group within the Oncology Research Unit and lead in vivo pharmacology strategy for ADC discovery programs. This role generates decision-enabling efficacy tolerability pharmacodynamic and translational data to advance ADC assets from early discovery through preclinical development. The ideal candidate will apply strong scientific judgment and broad oncology in vivo pharmacology expertise to integrate target biology ADC modality considerations biomarker strategy and study execution into clear recommendations for project teams.

Position Responsibilities

• Design oversee and interpret in vivo ADC pharmacology studies including efficacy dose and schedule optimization tolerability pharmacodynamic biomarker mechanism-of-action and combination studies.
• Serve as the in vivo pharmacology lead for ADC project teams by translating program questions into robust experimental plans and decision-enabling study packages.
• Incorporate tumor model selection antigen expression payload biology linker-payload properties pharmacokinetic/pharmacodynamic hypotheses and translational endpoints into study design.
• Partner with chemistry biologics translational medicine pathology bioanalytical toxicology and project leadership teams to define in vivo strategies and asset progression criteria.
• Provide scientific oversight for internal and external studies including protocol development CRO management data review issue resolution quality control and final interpretation.
• Analyze and communicate in vivo data through study reports project team updates and governance materials.
• Mentor junior scientists and technical staff in oncology model execution ADC pharmacology principles experimental design and data interpretation.
• Identify opportunities to improve in vivo workflows model characterization translational relevance and operational efficiency across oncology programs.

Minimum Qualifications / Key Skills

• Advanced degree in pharmacology cancer biology immunology biological sciences or a related field or a Bachelors/Masters degree with substantial relevant industry experience.
• Demonstrated experience designing and leading in vivo oncology pharmacology studies in pharmaceutical biotechnology academic or CRO settings.
• Strong understanding of ADC biology and pharmacology including target antigen biology payload class therapeutic index efficacy/tolerability relationships and translational biomarker strategy.
• Proven ability to build study strategies that test clear project hypotheses and support data-driven decisions.
• Experience interpreting tumor efficacy tolerability pharmacodynamic biomarker and dose-response datasets.
• Ability to manage multiple program priorities coordinate internal and external resources and deliver high-quality data on project timelines.
• Strong written and verbal communication skills with the ability to present complex scientific data clearly to multidisciplinary teams.
• Uses independent scientific judgment to shape program strategy and influence project direction through high-quality experimental design and interpretation.
• Demonstrates project team leadership and supports junior colleagues through coaching and technical guidance.

Preferred Qualifications

• Direct experience supporting ADC programs from early discovery through candidate selection or IND-enabling stages.
• Experience with patient-derived or cell line-derived xenograft models orthotopic models disseminated disease models or mechanistically relevant pharmacodynamic endpoints.
• Familiarity with bioanalytical pathology immunohistochemistry molecular profiling or omics approaches used to characterize ADC mechanism and response.
• Experience managing CRO studies including external study plans budgets timelines and data review workflows.
• Track record contributing to regulatory-enabling packages governance presentations publications or internal scientific strategy documents.

NON-STANDARD WORK SCHEDULE TRAVEL OR ENVIRONMENT REQUIREMENTS

Must be willing and able to work after hours as needed to ensure study integrity.

Relocation support available
Work Location Assignment:On Premise

The annual base salary for this position ranges from $88500.00 to $147500.00. In addition this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 10.0% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution paid vacation holiday and personal days paid caregiver/parental and medical leave and health benefits to include medical prescription drug dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits (). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN O-1 H-1B etc.) is not available for this role now or in the future.

To learn more about acceptable and prohibited uses of AI during the recruitment process please review our candidate AI-use guidelines available onPfizer Careers.

Research and Development