Senior Manager Statistical Programming

Join Us in Tackling Autoimmune Disease at Its Root

At Vor we believe science can do more than manage symptoms. It can change the course of disease. By advancing telitacicept a first- and potentially best-in-class dual BAFF/APRIL inhibitor we are silencing upstream survival signals and stopping downstream autoimmune cascades. Together we are addressing disease at its root cause and rewriting what is possible for patients worldwide.

When you join Vor youre not just working on a medicine. Youre part of a mission to redefine the future of autoimmune care.

Why Work at Vor

Impact: Contribute directly to a medicine with best-in-disease Phase 3 results in myasthenia gravis and expansion into multiple autoimmune diseases.

Growth: Be part of a rapidly scaling company with opportunities to grow your career in science clinical development commercial strategy and beyond.

Innovation: Work on a platform with potential beyond one indication a therapy that has already shown consistent results across lupus IgA nephropathy and Sjögrens syndrome.

Belonging: Join a culture where every voice is heard and where our shared mission unites us across functions and geographies.

Senior Manager Statistical Programming

Position Summary

The Senior Manager Statistical Programming will provide hands-on statistical programming leadership and support for assigned clinical studies and collaborate with Biostatistics Clinical Data Management Clinical Operations Safety and other study functions. This role is responsible for the design development validation and quality control of SAS programs used to access transform analyze report and submit clinical trial data.

The Senior Manager will serve as lead programmer for assigned studies provide technical guidance to project teams and ensure that programming deliverables are accurate consistent and completed within established timelines.

Essential Duties and Responsibilities

• Serve as lead study programmer and support review of statistical analysis plans development of mock TFLs programming dry runs and production of draft and final TFLs.

• Develop validate and maintain SDTM and ADaM datasets programming specifications metadata and support documentation.

• Program and validate tables figures and listings for efficacy safety pharmacokinetic pharmacodynamic and clinical outcome assessments.

• Design and develop efficient SAS programs macros and reusable utilities using Base SAS SAS Macro SAS/STAT SAS/GRAPH and ODS.

• Transform and integrate data from EDC systems IRT systems laboratories eCOA platforms and other external sources.

• Perform quality control reviews of SAS programs datasets specifications logs and outputs produced by other programmers.

• Investigate and resolve complex data derivation programming and reporting issues with limited supervision.

• Support database locks safety updates clinical study reports publications and other study deliverables.

• Support regulatory submissions through preparation and validation of SDTM ADaM SDRG ADRG annotated CRFs and related submission components.

• Review and resolve CDISC and submission validation findings.

• Apply MedDRA WHODrug controlled terminology and other applicable industry standards.

• Maintain clear traceability from source data through SDTM ADaM and final statistical outputs.

• Contribute to programming standards templates automation and process improvement initiatives.

• Provide technical guidance and peer review to less experienced programmers and contribute to their technical development as needed.

Knowledge and Skill Requirements

• Masters degree in Statistics Mathematics Computer Science or a related discipline.

• Minimum of 7 years of statistical programming experience in a pharmaceutical biotechnology or CRO environment.

• Strong hands-on SAS programming skills and experience with clinical trial reporting.

• Strong knowledge of CDISC standards including SDTM ADaM metadata controlled terminology data flow and FDA electronic submission requirements.

• Experience independently developing and validating analysis datasets programming specifications and TFLs.

• Demonstrated experience serving as a lead programmer for Phase 2 or Phase 3 clinical studies with the ability to independently manage study-level programming deliverables.

• Good understanding of clinical development medical data and common safety and efficacy domains.

• Strong analytical problem-solving debugging and quality-control skills.

• Ability to manage multiple study deliverables adapt to changing priorities and work effectively with cross-functional teams.

• Strong written and verbal communication skills.

• Experience in autoimmune disease neurology or rare-disease clinical development is preferred.

• Working knowledge of R or other programming technologies is desirable.

The salary range for this Senior Manager Statistical Programming position is expected to be between $190000 and $205000 per year. Individual pay may vary based on multiple factors including but not limited to relevant job-related skills experience education or training market factors and work location.

At Vor we support our team with robust benefits including comprehensive health coverage flexible paid time off generous parental leave and a competitive 401(k). From education assistance to wellness resources and financial security we invest in your well-being so you can thrive at work and beyond.

As an equal opportunity employer we at Vor Bio know that diversity inspires innovation inclusiveness and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race age color religion sex sexual orientation gender identity national origin veteran or disability status.

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