Senior Manager, Sample Management

Revolution Medicines is a global commercial-state oncology company dedicated to discovering developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform the company is advancing a broad integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active cancer-driving state of on rigorous scientific inquiry and a willingness to challenge long-held assumptions Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science challenge assumptions act with urgency and hold ourselves to a high standard of rigorall in service of patients.

The Opportunity:

• Provide direct hands-on leadership to sample management staff including daily work assignment prioritization and real-time problem solving.

• Lead and participate in core sample management activities including sample receipt storage tracking retrieval and disposal.

• Ensure smooth day-to-day operation of automated storage systems LIMS and supporting laboratory infrastructure.

• Train mentor and develop staff through on-the-job coaching feedback and performance management.

• Develop maintain and enforce SOPs and best practices for all critical sample management processes.

• Identify and implement process improvements to enhance efficiency reliability and scalability.

• Serve as the primary point of contact for cross-functional partners ensuring timely and accurate delivery of materials.

• Work closely with the Director of Sample Management to communicate capacity risks and resource needs.

• Support onboarding and ramp-up of new staff and technologies within the laboratory.

• Provide technical leadership and subject matter expertise in tissue culture including aseptic technique routine cell line maintenance culture optimization cryopreservation thawing and recovery.

• Lead the design and execution of fit-for-purpose cell banking strategies including the creation expansion characterization qualification release use and retirement of research master and working cell banks.

• Plan and oversee cell bank expansion activities including seed-train design passage management scale-up scheduling resource allocation and assessment of growth viability and recovery performance.

• Establish and maintain cell bank inventory controls that ensure unique identification accurate storage locations complete metadata chain of custody inventory reconciliation capacity planning and full lifecycle traceability.

• Define and enforce contamination-control practices for tissue culture operations including segregation strategies biosafety requirements cleaning and disinfection procedures and appropriate response to contamination events.

• Oversee cell bank quality assessments including cell identity or authentication sterility mycoplasma status viability morphology purity and other program-specific acceptance criteria.

• Provide expert troubleshooting for tissue culture and cell banking issues investigate deviations and performance trends determine root cause and implement effective corrective and preventive actions.

• Ensure cell culture and cryogenic equipment including biological safety cabinets incubators controlled-rate freezers and liquid nitrogen storage systems is appropriately qualified monitored maintained and fit for intended use.

• Partner with research teams to forecast cell line demand prioritize banking and expansion work establish service levels and deliver qualified cell stocks that meet program timelines.

• Lead technical transfer method standardization and training for tissue culture and cell banking processes including oversight of external vendors or contract laboratories when applicable.

Required Skills Experience and Education:

• BS/MS or equivalent degree in chemistry biology engineering or a related scientific discipline.

• 5-10 years experience in sample management compound management or laboratory operations.

• Proven experience directly supervising and leading technical staff in a laboratory environment.

• Hands-on experience with automated sample storage systems LIMS and laboratory automation tools.

• Strong attention to detail operational discipline and commitment to data integrity.

• A proven background in continuous improvement methodologies.

• Comfort operating in a fast-paced collaborative discovery environment.

• Clear and effective written and verbal communication skills.

Preferred Skills:

• Experience supporting small-molecule drug discovery programs.

• Experience training and mentoring early-career scientists or technicians.

• Exposure to process improvement initiatives or system implementations.

• Familiarity with vendor-managed laboratory automation platforms.

• Direct experience with Cenevos Sample Management Software Mosaic.

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