Senior Manager, Clinical Pharmacology & DMPK

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life increasing potential duration of life and resolving serious unmet medical needs. At Summit we believe in building a team of world class professionals who are passionate about this mission and it is our people who drive this mission to reality. Summits core values include integrity passion for excellence purposeful urgency collaboration and our commitment to people. Our employees are truly the heart and soul of our culture and they are invaluable in shaping our journey toward excellence.

Summits team is inspired to touch and help change lives through Summits clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies including:

Non-small Cell Lung Cancer (NSCLC)

• HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

• HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

• HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

• HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than Chinas National Medical Products Administration (NMPA). Summit is headquartered in Miami Florida and has additional offices in California New Jersey the UK and Ireland.

Overview of Role:

The Senior Manager Clinical Pharmacology & DMPK will manage clinical pharmacology pharmacokinetic (PK) drug metabolism (DM) and bioanalytical (BA) supports and operation for Summits assets. This role is responsible for PK and ADA samples management vendor management and perform data analysis to support projects.

Role and Responsibilities:

• Serve as Clinical Pharmacology and DMPK subject matter expert on cross-functional teams in both early- and late-stage projects

• Design and outsource in vitro and in vivo ADME studies to characterize the compounds

• Manage external vendors for bioanalysis including validation and sample analysis

• Oversee the collection processing storage tracking distribution and reconciliation of PK/ADA samples

• Ensure data integrity and compliance with Good Clinical Practice (GCP) regulations throughout the drug development process

• Collaborate with cross functional teams and central laboratories to manage sample logistics and chain-of-custody procedures

• Perform NCA data analysis/interpretation and reporting

• All other duties as assigned

Experience Education and Specialized Knowledge and Skills:

• Ph.D. Pharm.D. or equivalent training in pharmacokinetics pharmaceutical sciences or related disciplines with 1 years of clinical pharmacology industry experience or M.S. with 5 years of relevant experience

• Experience in clinical trial design and execution preferably in various phase clinical studies

• Understanding of clinical pharmacology concepts and conducting clinical pharmacology studies and knowledge of regulatory requirements related to clinical trials (GCP ICH guidelines) and drug development

• Hands-on experience with standard PK Software (e.g. Phoenix WinNonlin).

• Strong project management skills and ability to prioritize and manage multiple projects simultaneously

• Excellent communication organizational and problem-solving skills

Actual compensation packages are based on several factors that are unique to each candidate including but not limited to skill set depth of experience certifications and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus stock benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summits Talent Acquisition team atto obtain prior written authorization before referring any candidates to Summit.

Summit Therapeutics an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment. We do not discriminate in recruitment hiring training or promotion or any other employment practices for reasons of race color religion gender national origin age sexual orientation marital or veteran status disability or any other legally protected status.