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Senior Endpoint Systems Engineer (HYBRID Chicago)

Ambry Genetics


Job Location:

Chicago, IL - USA

Yearly Salary: $ 130000 - 145000
Posted: 22 August 2026 (15 days ago)
Application Deadline: 19 November 2026
Vacancies: 1 Vacancy

Job Summary

Passionate about precision medicine and advancing the healthcare industry

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time actionable insights to physicians providing critical information about the right treatments for the right patients at the right time.

Location: Hybrid: Chicago (3 days on-site)

Position Overview:

We are seeking a highly skilled and strategic Senior Endpoint Systems Engineer to join our IT this role you will serve as the primary architect and technical lead for the health security compliance and lifecycle management of our global endpoint fleet.
Our environment features a balanced mix of both Windows and macOS devices. We need a senior professional with deep dual-platform expertise who can design scalable deployment workflows architect robust endpoint security configurations and optimize our enterprise toolsetspecifically Microsoft Intune Jamf Pro and Workspace ONE. As a senior member of the team you will drive technical strategy lead complex integration projects and mentor junior IT staff to ensure a seamless and secure digital employee experience.

Key Responsibilities:
  • Enterprise MDM Architecture: Architect optimize and maintain our global Unified Endpoint Management (UEM) infrastructure using Microsoft Intune Jamf Pro and VMware Workspace ONE.
  • Strategic Fleet Engineering: Design and scale automated deployment provisioning and configuration management workflows for a balanced fleet of Windows 10/11 and macOS hardware.
  • Modern Provisioning & Lifecycle: Standardize and evolve modern deployment frameworks utilizing Windows Autopilot Apple Business Manager (ABM) and Automated Device Enrollment to achieve zero-touch provisioning.
  • Advanced Scripting & Automation: Develop test and maintain robust code repositories (PowerShell for Windows; Bash/Zsh/Python for macOS) to automate complex administrative tasks custom reporting and API integrations.
  • Security & Compliance Governance: Partner closely with the Security team to engineer and enforce endpoint security baselines (e.g. CIS Benchmarks) disk encryption protocols (BitLocker FileVault) and EDR/antivirus agent deployments.
  • Identity & Access Architecture: Lead the integration of endpoint platforms with enterprise identity and access management (IAM) systems (e.g. Entra ID Okta) including modern single sign-on (SSO) extensions.
  • Tier 3/4 Escalation & Mentorship: Act as the highest tier of technical escalation for complex endpoint OS and software issues. Provide mentorship guidance and technical training to Tier 1/2 service desk and junior systems administrators.
  • Roadmapping & Documentation: Maintain a forward-looking roadmap for endpoint technologies evaluate emerging tools and author authoritative architectural diagrams and standard operating procedures (SOPs).

Required Skills & Qualifications:
  • Experience: 58 years of dedicated experience in endpoint engineering systems administration or infrastructure architecture within an enterprise environment.
  • Dual-Platform Mastery: Comprehensive expert-level knowledge of both Windows and macOS operating systems system internals and enterprise deployment methodologies.
  • Enterprise Tooling Expertise: Deep hands-on engineering experience configuring and managing Microsoft Intune Jamf Pro and Workspace ONE at scale.
  • Advanced Scripting: Strong proficiency in PowerShell and Bash/Zsh (Python or Swift is a significant plus) for advanced automation custom scripts and utilizing MDM APIs.
  • Leadership & Communication: Proven ability to lead projects independently collaborate across multi-functional engineering teams and explain complex technical concepts to non-technical stakeholders.

$130000-$145000 annually

The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California Colorado New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits which may include incentive compensation restricted stock units medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race religion color national origin gender sexual orientation age marital status veteran status or disability status.


Required Experience:

Senior IC


About Company

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Ambry delivers high-quality, accessible genetic testing for hereditary cancer and exome sequencing for rare disease. A trusted lab for 25 years.

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