Senior Director, Internal Medicine Portfolio Strategy Lead

The Senior Director IM Portfolio Strategy Lead is a senior individual contributor role within the Internal Medicine and Antivirals business part of the Global Commercial Strategy organization reporting to the VP GCS IM/AV. This role has no current direct reports and will lead through influence and senior matrixed leadership. The roleis responsible forleading portfolio-level strategy prioritization investment decision support and enterprise-ready strategic recommendations across the Internal Medicine and Antivirals portfolio. The colleague will bring deep commercial strategy experience analytical rigor scientific curiosity and enterprise judgment to help shape portfolio choices pipeline opportunities lifecycle priorities and external innovation strategy.

The Internal Medicine and Antivirals portfoliorepresentssignificant strategic value to realizing Pfizers vision to achieve leadership via breakthroughs in prioritized diseases to generate highly differentiated multi-indication mega-blockbusters. Today the portfolio delivers more than $11B globally.

This colleague will serve as a senior portfolio strategy partner to the VP GCS IM/AV DALs and cross-functional leaders helping translate scientific clinical market access competitive and business insights into clear portfolio priorities and disciplined trade-off decisions. The role will support strategic planning across near- mid- and long-term horizons and ensure that portfolio recommendations are grounded in patient need scientific opportunity market potential access dynamics and enterprise value.

This role requires an experienced commercial strategist who canoperateacross ambiguity influence senior stakeholders without direct authority and connect work across disease areas assets lifecycle opportunities and external innovation. The Senior Director will helpestablishrepeatable approaches decision frameworks and AI-enabled ways of working that improve the quality consistency and speed of portfolio strategy development across Internal Medicine and Antivirals.

Responsibilities:

Portfolio Strategy and Long-Range Planning:

• Lead development of long-range commercial and portfolio strategy across the Internal Medicine and Antivirals portfolio spanning pipeline assets lifecycle opportunities external innovation and emerging disease-area opportunities.

• Establish integrated near- mid- and long-term views of portfolio opportunities risks and investment priorities to inform enterprise decision-making.

• Synthesize scientific clinical commercial access competitive financial and patient insights toidentifypriority opportunities and strategic trade-offs.

• Monitor shifts in the scientific competitive and market landscape toidentifyemerging trends discontinuities and implications for future Internal Medicine and Antivirals strategy.

• Translate portfolio strategy into clear recommendations implications and decision materials for leadership governance forums and cross-functional portfolio discussions.

Portfolio Prioritization and Investment Decision Support:

• Provide senior commercial strategy leadership for portfolio prioritization investment choices and development opportunities across Internal Medicine and Antivirals priorities.

• Pressure-test commercial assumptions value drivers risks uncertainties resource implications and evidenceneedsthat may influence future launch potential lifecycle value and portfolio performance.

• Lead development of executive-ready materials that communicate strategic rationale opportunity attractiveness trade-offs scenarios and recommended actions.

• Partner with cross-functional leaders toalign onkey choices related to portfolio sequencingindicationprioritization evidence generation market development and lifecycle opportunities.

• Support disciplined decision-making by ensuring portfolio recommendations are grounded in patient need scientific opportunity market potential access dynamicsfinancial impact and enterprise value.

Early Commercial Assessment and Product Concept Development:

• Oversee early commercial assessments for pipeline assets mechanisms indications disease-area opportunities and potential future product concepts across Internal Medicine and Antivirals.

• Guidedevelopment and refinement of product concepts target product profile input positioning hypotheses market archetypes commercial opportunity assessments and forecast assumptions.

• Ensure unmet need standard of care competitive dynamics patient/HCP insights payer considerations and access requirements are translated into differentiated commercial hypotheses.

• Provide portfolio-level commercial input to clinical development evidence generation lifecycle andindicationsequencing discussions in partnership with cross-functional colleagues.

• Build repeatable approaches for high-quality early commercial strategy outputs portfolio reviews and decision-support materials across Internal Medicine and Antivirals workstreams.

Business Development and External Innovation Support:

• Lead portfolio strategy input for external innovation and Business Development opportunities relevant to Internal Medicine and Antivirals.

• Guideassessment of strategic fit market potential valuation inputs competitive scenarios portfolio implications and prioritization considerations for potential external opportunities.

• Partner with Business Development R&D GASP BAI and Competitive Intelligence colleagues to pressure-test assumptions andidentifykey decision points.

• Represent the commercial portfolio strategy perspective in internal discussions related to external opportunities and broader Internal Medicine and Antivirals strategy as needed.

Cross-Functional Partnership and Governance:

• Provide senior matrix leadership across cross-functional partners helping align priorities clarify decision points and strengthen high-quality strategic outputs across Internal Medicine and Antivirals portfolio priorities.

• Partner with the VP GCS IM/AV DALs and cross-functional leaders to ensure a strong commercial and portfolio strategy voice is incorporated into early development portfolio and investment decisions.

• Influence without direct authority by aligning stakeholders around shared insights strategic choices and implications for the Internal Medicine and Antivirals portfolio.

• Build trusted working relationships across R&D Medical Affairs GASP BAI Competitive Intelligence Business Development Finance and Commercial Regions.

• Foster a culture of enterprise thinking scientific curiosity disciplined prioritization accountability and collaboration across cross-functional workstreams.

AI-EnabledWays of Working:

• Set expectations for responsible AI-enabled ways of working across portfolio strategy workstreams to improve speed quality consistency and scalability of strategic outputs.

• Champion use of AI-enabled tools to support scientific and competitive landscape synthesis market insight generation scenario development prioritization and decision-support efficiency.

• Help build cross-functional capability and confidence in compliant AI-augmented strategy development through best-practice sharing and reinforcement of quality standards.

• Identifyopportunities to embed AI into repeatable workflows templates portfolio reviews scenario planning and strategic decision-support processes.

• Use performance insights stakeholder feedback and workstream learnings to continuously improve AI-enabled ways of working across portfolio strategy activities.

Here Is What You Need (Minimum Requirements)

• Applicant must have a bachelors degree with at least 12 years of experience; OR a masters degree with at least 10 years of experience; OR a PhD with 7 years of experience

• Experience in pharmaceutical biotechnology life sciences commercial development portfolio strategy corporate strategy business development forecasting market research analytics or relatedfield.

• Demonstrated experience leading complex cross-functional initiativesinfluencing inmatrixed environments and shaping senior-level portfolio or investment decisions without direct authority.

• Strong strategic and analytical skills withabilityto synthesize complex scientific clinical market access and competitive information into clear recommendations.

• Experience leading portfolio strategy early commercial assessment business case development opportunity assessment investment prioritization or cross-functional strategic planning.

• Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity differentiation portfolio value and enterprise decision-making.

• Strong communication executive presence problem-solving and stakeholder management skills.

Bonus Points If You Have (Preferred Requirements)

• Experience in Internal Medicine Antivirals cardiometabolic disease specialty care primary care or other complex therapeutic areas preferred.

• Experience with commercial development early asset strategy portfolio management Business Development assessments launch strategy lifecycle strategy or corporate strategy.

• Demonstrated ability to develop long-term strategies for products disease areas or portfolios and secure alignment from senior leadership.

• Understanding ofmarket access dynamics payer considerations evidence generation value demonstration and lifecycle value optimization.

• Track recordof leading cross-functional initiatives influencing without authority acting decisively and making recommendations with incomplete imperfect or disparate information.

• Comfort working in an AI-enabledor AI-augmented environment; experience using AI tools to support strategy synthesis or analysis is a plus.

• Ability to thrive in ambiguityoperatewithenterprisemindset and adapt to evolving portfolio priorities.

• Robust operational experiencevis-à-visbuilding tacticalplans to pull throughstrategicprioritiesnegotiatingtheoptimalOpExandA&Pinvestmentinthe go-to-marketmodelandpromotionalplanspanningcore andinnovative commercial levers andpreservingor improvingCoGSand gross-to-netliability

• Discretion sound judgment and trustworthiness in handling confidential or sensitive organizational matters.