Scientist, Solid Tumor CAR-T

Legend Biotech is a global biotechnology company dedicated to treating and one day curing life-threatening diseases. Headquartered in Bridgewater New Jersey we are advancing the next generation of cell therapy through a portfolio of innovative technologies including autologous allogeneic and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T) T-cell receptor (TCR-T) natural killer (NK) cell-based therapies and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites we are committed to discovering and developing safe effective and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

Legend Biotech is seeking a Scientist Solid Tumor CAR-Tas part of the Research and Development team based in Philadelphia PA.

Role Overview

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.

The ideal candidate holds a PhD in Immunology Immuno-Oncology or a closely related discipline with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Key Responsibilities

• Design and execute in vitro CAR-T functional assays.
• Perform comprehensive phenotypic analysis of T cell differentiation activation and memory subsets.
• Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
• Handling and engineering human and murine T cells as well as various cancer cells.
• Engineering and maintaining various cancer cell lines for model development.
• Analyze and interpret data troubleshooting maintain detailed experimental records.

Requirements

• A scientist in Immunology Immuno-Oncology Tumor Immunology Cancer Biology or a closely related field.
• Candidates completing ther PhD within the past 3 years are strongly encouraged to apply.
• Primary human T cell isolation activation lentiviral transduction and expansion is required.
• Multicolor flow cytometry: panel design data acquisition (e.g. AttuneNovocyte Cytek Aurora) and analysis (FlowJo).
• Standard molecular biology: PCR/qPCR lentiviral vector packaging and titration Western blot.
• Experience with humanized mouse models for in vivo CAR-T evaluation.
• Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections in vivo imaging.
• Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
• Experience with in vitro Organoid cancer model establishment and expansion.
• Experience in solid tumor indications (e.g. lung gastric or other refractory cancers).
• Contributions to innovation in cell therapy (publications patents or conference presentations).

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations we participate in the E-Verify program. If you are selected for employment you will be required to complete the Form I-9 process and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair transparent and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race color creed religion national origin ancestry citizenship status age sex or gender (including pregnancy childbirth related medical conditions and lactation) gender identity or gender expression (including transgender status) sexual orientation marital status military service and veteran status disability genetic information or any other protected characteristic under applicable federal state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.