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Scientist II, Biomolecular Characterization
Job Location:
Job Location:
San Mateo, CA - USA
Yearly Salary:
USD 145000 - 165000
Yearly Salary:
Posted:
2 September 2026 (8 days ago)
Posted:
Application Deadline:
1 December 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
The role: BigHat Biosciences is seeking an exceptional individual for a Scientist II or Senior Scientist I in Biomolecular Characterization* role to drive characterization of in vitro antibody-target binding behavior develop new assay capabilities and represent the team across BigHats programs.
*At BigHat we believe in titles that are commensurate with skill set relative organizational impact and value contribution; more or less experienced candidates are encouraged to apply with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
- Develop optimize and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
- Implement best practices for binding assay design across various bioanalytical assay formats.
- Troubleshoot and diagnose assay issues building foundational understanding of antibody/antigen interactions that stakeholders can act on.
- Collaborate closely with BigHats science organization to accelerate hits from discovery through lead optimization and candidate nomination.
- Effectively synthesize and communicate results and research activity to key decision makers and the broader BigHat team.
- Partner with automation engineering software engineering and production teams to scale and productionize high-throughput kinetics assays.
Skills Knowledge and Expertise
- Ph.D. 2-5 years or with 5 years of independent research and development experience in an industry setting including substantial experience with binding assays including BLI SPR ELISA/MSD and Flow Cytometry workflows (preferably across Carterra Cytiva and Sartorius instrumentation).
- Practical and theoretical fluency in bioanalytical science biochemistry biophysics assay design and development (experience in both complex and buffered matrices preferred).
- Experience with lab automation and working with automation engineers (preferred).
- Strong data analysis and interpretation skills coupled to exceptional written verbal and visual communication skills.
- Ability to educate and build consensus among diverse stakeholders regarding scientific direction.
Total Rewards
The salary estimated for this position is $145000 - $165000 bonus options benefits. Compensation will vary depending on job-related knowledge skills and experience. Actual compensation will be confirmed in writing at the time of the offer.
Required Experience:
IC
About Company
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these desig ... View more
