Scientist 2

Introduction:Xencor is a public clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb bispecific T-cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms and we are advancing our pipeline toward clinical proof-of-concept decisions. Our goal is to create high-impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates engineered with our technology are in clinical development and three XmAb medicines have been marketed by partners. For more information please visit . We have an excellent opportunity for a Scientist 2 to join our : We are seeking a highly motivated and skilled individual to join our Antibody Discovery team. This open position is an exciting opportunity to impact the next wave of biologic candidates to enter our pipeline. The successful candidate should have general in vitro antibody display experience with special emphasis on yeast display. The ideal candidate will work to optimize a yeast-display discovery platform and participate in antibody library design and construction. The candidate will collaborate with scientists from different functional groups and conduct in vitro display campaigns to identify novel therapeutic hits and optimize leads against a wide range of targets and diseases. Candidates should have a demonstrated record of technical proficiency and ability to work effectively with a diverse group of researchers in a team environment. Job Duties Include: Perform yeast display-based discovery screens to support new and ongoing therapeutic NGS including NGS library generation QC sequencing and data analysis for hit display-based lead optimization including design and building of new display libraries QC and screening. Stay current with external advancements in relevant scientific fields and scientific strategies review data in real-time and make the necessary experimental adjustments to ensure successful delivery of yeast display discovery research & development efforts with other departments to prioritize critical experiments for advancing discovery and presents data in group and departmental meetings as all laboratory safety guidelines practices and to the design and execution of experiments analysis interpretation of data and reporting and archiving of results. Adhere to all department and company-wide policies regarding conduct performance and provide direction to direct and indirect reports as applicable in accordance with the organizations policies and procedures. Attend to daily laboratory operations including the maintenance of equipment inventories consumables reagents and other other duties as requires a Ph.D. in a relevant scientific field with at least 3 years of post-graduate laboratory work experience; previous industry experience is preferred. Requires prior experience collaborating on project teams matrixed across functions including contract laboratories and corporate partners and strong research study experience. Requires sound theoretical and experimental experience in a relevant scientific field coupled with technical proficiency scientific creativity collaboration with others and independent thought. Small company and industry work experience preferred. Position also requires:Strong hands-on experience with yeast display including building naïve and/or immunized with antibody lead optimization including affinity potency and developability in molecular cloning and utilization of DNA analysis software (Geneious Prime Sequencher or similar software).Experience in NGS technology including NGS library generation QC sequencing and sequence with AI / ML sequence analysis would be understanding of antibody structure function and with high throughput screening (96 and 384-well plates) and liquid handling automation is -site presence with time split between lab (80%) and non-lab activities (20%).Excellent verbal and written communication skills; ability to communicate clearly and effectively with scientific colleagues and management by contributing sound scientific concepts ideas and analytical assessment and problem-solving to perform method development write protocols maintain detailed records and use an electronic notebook are required. Experience with Benchling as an ELN and database is to read analyze interpret and communicate complex data and in software and data analysis packages like Microsoft Office (Word Excel Outlook PowerPoint) Spotfire FloJo and GraphPad to effectively collaborate coach and mentor others through scientific and technical to work in a fast-paced goal-oriented multi-project environment with adaptability to changing priorities and capacity to excel working on a team and individually is to demonstrate competencies applicable for job based on Xencors Leadership Competency organizational and interpersonal skills attention to detail and professional competencies in oral and written communication are contribute to authoring of scientific documents as Requirements for Laboratory and Research Related JobsThis role may involve work with experimental subjects and/or specimens including infected samples plus various Hazardous Materials and infectious agents (Bloodborne Pathogens or other potentially infections materials (OPIMs). Therefore the following are also required:Ability to follow the established Environmental Health & Safety rules procedures and/or BioSafety GuidelinesAbility to read and understand Safety Data Sheets (SDSs)Ability to be available and willing to work some weekends and evenings to conduct and complete experimentsKnowledge of biosafety techniques and aseptic/gowning practicesExperience with laboratory safety standards and procedures including biohazard handling and disposal techniques and the ability to ensure laboratory compliance with required safety regulationsExperience working with biological and chemical hazards infectious agents bloodborne pathogens and animal allergensExperience working in and maintaining a sterile environmentExperience working with chemical and biological hazards Thorough knowledge of the operation and maintenance of various lab equipment such as microscopes centrifuges spectrophotometers balances pH meters and electrophoresis equipment freezers and Base Salary Range: $118000 - $150000The actual salary will be based on the selected candidates qualifications including skills competencies education and offers a competitive total rewards package including 401k match healthcare coverage ESPP and a broad range of other addition this position will be eligible for an annual bonus and equity grant. For more information please see with Disabilities Act (ADA) StatementThe Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process please contact perform this job successfully an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential Employment Opportunity (EEO) StatementThe Company is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to age race color religion sex sexual orientation gender or gender identity national origin disability status protected veteran status or any other characteristic protected by state or federal does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor implied or otherwise.