Research Data Analyst

Site: The McLean Hospital Corporation

Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

Summary
The Research Data Analyst will work under the direction of the Principal Investigator to support collaborative research integrating genomic and multi-omic data with clinical and electronic health record (EHR) data. The analyst will contribute to projects investigating the genetic epigenetic and downstream molecular basis of psychiatric and related complex traits.
Does this position require Patient Care
No
Essential Functions
-Perform statistical analyses of genomic and molecular data including polygenic risk score (PRS) analyses and association testing.
-Integrate genetic transcriptomic methylomic clinical and EHR phenotype data to investigate relationships between molecular variation and clinical outcomes.
-Analyze high-dimensional transcriptomic and DNA methylation datasets.
-Train genetically regulated gene expression (GReX) models and conduct transcriptome-wide association studies (TWAS).
-Perform differential expression and association analyses using statistical frameworks such as limma and related R/Bioconductor tools.
-Organize curate and analyze clinical and EHR-derived phenotype data including data collection harmonization quality control and phenotype definition.
-Develop and maintain reproducible analysis pipelines in R and/or Python.
-Conduct data quality control visualization statistical modeling and interpretation of results.
-Organize document and maintain research datasets and analysis outputs to facilitate reproducibility and collaboration.
-Work closely with investigators on study design analysis interpretation and preparation of results for presentations and manuscripts.

Education
Bachelors or Masters degree in bioinformatics biostatistics computational biology data science statistics genetics/genomics or a related quantitative field required.

Can this role accept experience in lieu of a degree
Yes

Experience
Experience attained through education or 01 year of relevant research or data-analysis experience required. Academic research internships or coursework involving statistical analysis or biomedical data may satisfy this requirement.

Knowledge Skills and Abilities

• Proficiency in R and statistical data analysis; experience with Python is desirable.
• Experience working with large complex or high-dimensional biomedical datasets.
• Familiarity with genomic transcriptomic DNA methylation or other molecular data.
• Familiarity with PRS GWAS TWAS/GReX limma or related genomic analysis methods is desirable.
• Familiarity with clinical or EHR data including phenotype curation and harmonization is desirable.
• Understanding of statistical modeling data visualization and data quality-control methods.
• Strong organizational skills and the ability to maintain well-documented and reproducible analyses.
• Ability to work collaboratively with investigators scientists clinicians and interdisciplinary research teams.
• Ability to identify analytical or data-related roadblocks and seek appropriate guidance.
• Strong computer skills and careful attention to data accuracy and organization.

Hybrid

115 Mill Street

40

Regular

Day (United States of America)

Pay Range

$41932.80 - $60340.80/Annual

Grade

5

At Mass General Brigham we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive and any offer extended will take into account your skills relevant experience if applicable education certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however it does not encompass all elements contributing to your total compensation addition to competitive base pay we offer comprehensive benefits career advancement opportunities differentials premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

1600 The McLean Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .