Research Associate, Computational Protein Engineering (Contract)

Job Summary:

Zymo Research is seekinga highly motivated and innovative Computational Protein Research Associate to join our multidisciplinary research team focused on protein engineering enzyme discovery antibody design and AI-driven molecular modeling.

The successful candidate will work at the intersection of computational biology machine learning structural biology and protein engineering. Key responsibilities will include developing scalable protein sequencestructurefunction analysis platforms building predictive AI/ML models and identifying or designing proteins with desired biological properties. This role offers the opportunity to contribute tocutting-edgeplatform technologies in enzymes antibodies synthetic biology and molecular diagnostics.

Join us in making a meaningful impact!

Essential Duties and Responsibilities

• Apply protein language models and other machine-learning approaches including model fine-tuning to analyze protein sequences predict molecular properties and annotate protein functions.
• Use structural modeling and simulation tools including AlphaFold 3 Rosetta and molecular dynamics simulations to investigate protein structures conformational stability molecular interactions and functional mechanisms.
• Apply AI/ML methods to de novo protein design protein optimization enzyme engineering antibody design and functional prediction.
• Perform computational screening and prioritization of candidate proteins for experimental validation.
• Collaborate closely with wet-lab scientists to design experiments interpret results and iteratively improve engineered proteins.
• Contribute to active-learning-driven DesignBuildTestLearn cycles for protein engineering and optimization.
• Presentresearch findings internally and externally through reports publications and scientific conferences.
• Contribute to intellectual property generation and platform development.

Education and Experience:

• Bachelors degree or higher in computational biology bioinformatics structural biology computer science biophysics protein engineering or relatedfield.

• Strong foundation in computational protein science or structural biology.

• Experience applying machine-learning or deep-learning methods to biological sequence structure or functional data.

• Proficiency in Python and commonly used scientific computing and machine-learning libraries.

• Experience with protein language models structure-based modeling or molecular simulation is highly desirable.
• Strong analytical problem-solving and communication skills.
• Ability to work independently while contributing effectively within a multidisciplinary research environment.

About Us:

Since its inception in 1994 Zymo Research has been proudly serving the scientific community by providing innovative reliable and high-quality research tools and products. Whether its DNA RNA epigenetics microbiomics protein or yeast-based research our philosophy remains the same: To provide the highest quality products in the industry while ensuring they are both simple to use and reliable in their performance.

Recognized as a Top Workplace by the Orange County Register inand named a Top Workplace USA in 2023 Zymo Research continues to be a vibrant community where employees thrive feel connected and are inspired by their work. If you are passionate about contributing to scientific advancement and want to be part of an exceptional team in a dynamic growing company wed love to hear from you!

Compensation Benefits and Perks:

The estimated base compensation range for this position is $ at the time of posting. Actual compensation details will be provided in writing at the time of offer if applicable and is based on several factors we believe fairly and accurately impact compensation including geographic location experience knowledge skills abilities and other job permitted factors.

Zymo Research also offers competitive benefits and perks including:

• Medical Dental Vision and Life Insurance Coverages
• EAP Sessions
• Vacation Time plus Company Holidays
• Paid Sick Leave
• Generous 401(K) with matching
• Employee Referral Bonus
• Complimentary fruit snacks and beverages
• Complimentary catered lunches on Thursdays
• Complimentary EV Charging
• Cell phone stipend

Equal Employment Opportunity Employer:

Zymo Research welcomes candidates of all backgrounds. These include sex age color race religion marital status national origin ancestry sexual orientation gender gender identity gender expression physical & mental disability medical condition genetic information military and veteran status or any other protected status as defined by federal state or local law.

Location:

Onsite ZymoResearch 2961 Dow Ave Tustin CA 92780

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