Principal Software Engineer, Neuroscience Platforms

At Astera Neuro we are deciphering how activity across billions of neurons becomes thought perception and the conscious experience of the world and ourselves. Doing that requires building cutting-edge tools and infrastructure to interface with record and control neural activity at an unprecedented scale.

We are hiring a Principal Software Engineer to lead the computational infrastructure that the next generation of large-scale neuroscience research will depend on. Working closely with scientists and hardware engineers you will span the full stack of our research systems including instrument control data acquisition and analysis translating open-ended experimental goals into reliable software. The problems are latency-sensitive multi-modal and deeply interdisciplinary. You do not need a background in neuroscience to apply; we are looking for an exceptional pragmatic engineer who enjoys solving hard interesting problems and picks up the science as they go.

As a principal engineer you will define the technical roadmap across systems mentor other engineers and shape how neuroscience and engineering work together at Astera.

• Stimulus presentation and acquisition systems including VR environments built in Unity Unreal or comparable frameworks that synchronize peripheral streams (eye tracking displays haptics) with high-throughput neural recording hardware to millisecond precision.

• High-throughput pipelines to ingest process and store massive multi-modal neural datasets (electrophysiology calcium imaging behavior) with versioned data formats automated QC and clear metadata standards.

• Dashboards user interfaces and experiment-design tools that let scientists interact with complex data and run experiments seamlessly.

• Cloud-based storage processing and sharing infrastructure that supports distributed teams and large-scale datasets.

• Exceptional software engineering fundamentals proven in production. You write clean testable well-documented code and approach system design thoughtfully.

• The range and independence to take a rough idea or open-ended goal scope a path to a working system and move forward without waiting for a complete spec.

• A deep intuition for latency hardware limits and data bottlenecks earned building real-time or performance-critical systems in production (game engines robotics embedded systems audio/video pipelines or similar).

• Proficiency in at least two of: Python C C# Rust.

• Intellectually curious collaborative and eager to learn the science around you.

• A track record of owning complex systems end-to-end from architecture and implementation through operational reliability and of making and defending technical tradeoffs across performance maintainability and team velocity.

• Comfort working across the full stack from low-level hardware interfaces to cloud infrastructure with the ability to build and iterate on human-facing research systems with speed and taste.

• A history of mentoring engineers and leading technical initiatives with the judgment to set technical direction across teams.

• Familiarity with brain-machine interfaces neural data acquisition systems neural data formats and analysis tools.

• Background in machine learning particularly online/streaming inference or neural decoding.

• Experience designing data pipelines at scale (Airflow Prefect or similar orchestration tools).

• Experience with GPU-accelerated computing (CUDA Vulkan compute shaders).

• Familiarity with laboratory hardware integration (DAQ systems TTL synchronization serial/SPI protocols).

• Contributions to open-source neuroscience or scientific computing projects.

Backgrounds in computer science electrical engineering biomedical engineering neuroscience physics or related fields are all welcome. Graduate work or research experience in neuroscience or a related discipline is a plus but not required.

Astera Neuro is a neuroscience research company deciphering how activity across billions of neurons becomes thoughts perceptions and the conscious experience of the world and ourselves. We develop cutting-edge hardware recording systems and software with the goal of enabling the next generation of discoveries about neural circuits cognition and behavior.

The posted salary range is based on location in the Bay Area. The successful candidate will receive a competitive compensation package commensurate with their experience and location.

Required Experience:

Staff IC