Principal Scientist, Translational Science Program Lead, Immunology

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge Massachusetts United States of America Spring House Pennsylvania United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

About Immunology

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for a Principal Scientist Translational Science Program Lead Immunology for Immunology programs spanning discovery through clinical development. This role is located onsite in either Cambridge MA or Spring House PA.

The TSPL will be the scientific and strategic owner of the end-to-end translational strategy for assigned assets translating therapeutic mechanism and human disease biology into decision-linked evidence plans that guide portfolio entry dose and regimen selection proof of biology patient stratification clinical development and regulatory strategy.

The successful candidate will lead through scientific credibility and influence in a highly matrixed environment. They will anticipate upcoming program decisions integrate expertise across functions and mobilize teams toward clear recommendations and execution. This role requires deep immunology expertise strong translational judgment proficiency with multidimensional biomarker data and the ability to communicate complex evidence uncertainty trade-offs and recommendations to project teams and governance bodies.

• Own the translational strategy: Develop and maintain integrated stage-appropriate translational plans that connect disease biology therapeutic mechanism pharmacology biomarkers clinical endpoints and key program decisions.
• Anticipate evidence needs: Work one or more inflection points ahead to define critical questions evidence requirements decision criteria timelines dependencies risks and mitigation options.
• Lead precision medicine strategy: Develop testable hypotheses for disease segmentation patient stratification or selection response and non-response and clinically meaningful biomarker endpoints; integrate these hypotheses into target product profiles study designs and stage-gate decisions.
• Translate science into clinical plans: Define biomarker strategies addressing target engagement pharmacodynamic activity proof of biology dose and regimen selection disease heterogeneity efficacy safety and differentiation.
• Lead in the matrix: Represent Translational Science on discovery and clinical development teams and align Discovery Clinical Development Translational Medicine Clinical Pharmacology Data Science Biostatistics Diagnostics Regulatory Clinical Operations Commercial and other partners around an integrated recommendation.
• Ensure execution readiness: Partner with study leads laboratory scientists operations teams and vendors to translate strategy into fit-for-purpose assays sampling plans analysis plans data-delivery timelines budgets and contingency plans.
• Interpret integrated evidence: Lead the analysis and interpretation of preclinical clinical and high-dimensional datasets including transcriptomic genomic proteomic cellular tissue and other multimodal data to generate actionable biological and clinical insights.
• Drive decisions and manage risk: Communicate what is known what remains uncertain why it matters and what action is recommended. Surface risks early with options trade-offs mitigation plans and a preferred path.
• Strengthen the portfolio: Use human data and biospecimens to support target validation indication prioritization back-translation lifecycle strategy and reuse of evidence assays and learnings across assets.
• Lead external innovation: Establish and direct collaborations with academic investigators consortia contract research organizations technology providers and external experts to close defined strategic or capability gaps.
• Support regulatory and scientific communication: Author or provide strategic input to translational plans protocols analysis plans investigators brochures INDs and other regulatory submissions clinical study reports abstracts manuscripts and governance presentations.
• Build organizational capability: Mentor scientists and study leads model rigorous and inclusive scientific leadership contribute to functional strategy and standards and identify emerging technologiesincluding responsible applications of AI and advanced analyticsthat improve decision quality and portfolio execution.

What Success Looks Like

• Translational plans are explicitly linked to asset decisions and arrive early enough to influence them.
• Biomarker strategies are focused feasible scalable and supported by clear hypotheses contexts of use and analysis plans.
• Cross-functional teams understand the integrated evidence key uncertainties trade-offs and recommended path.
• Assays samples data vendors budgets and regulatory documentation are ready for critical program milestones.
• Precision-medicine and back-translation opportunities are incorporated from the outset rather than added after study design.
• Scientific standards capabilities and learnings are shared across the Immunology portfolio.

Required Qualifications

• PhD or MD/PhD in immunology translational medicine molecular or cellular biology pharmacology or a related scientific discipline.
• At least 5 years of relevant post-degree experience with substantial experience in the pharmaceutical or biotechnology industry strongly preferred.
• Demonstrated experience developing and executing translational or clinical biomarker strategies for drug discovery or development programs.
• Strong knowledge of immunology and immune-mediated disease biology with the ability to connect mechanism of action to measurable human biology and clinical outcomes.
• Experience with biomarker applications such as target engagement pharmacodynamics proof of biology patient stratification or selection disease activity dose selection and treatment-response assessment.
• Demonstrated success leading cross-functional initiatives and influencing decisions without direct authority in a matrixed environment.
• Experience interpreting complex translational datasets and partnering with quantitative scientists to develop rigorous decision-relevant analyses.
• Understanding of fit-for-purpose assay development validation clinical implementation sample and data flows and work with external laboratories or research partners.
• Strong written and verbal communication skills including the ability to tailor scientific narratives for technical teams senior leaders and governance audiences.
• Ability to prioritize across multiple programs operate effectively amid ambiguity and deliver high-quality work against demanding timelines.

Preferred Qualifications

• Expertise in rheumatology autoantibody-mediated disease B-cell or plasma-cell biology immune reset or another area relevant to the Immunology portfolio.
• Experience supporting programs from late discovery or candidate selection through early clinical development and into late-stage development.
• Experience integrating tissue peripheral blood single-cell flow cytometry transcriptomic proteomic or other multimodal data.
• Experience with precision-medicine diagnostic or companion-diagnostic strategies and associated regulatory considerations.
• Experience contributing to regulatory interactions or authoring translational content for regulatory submissions and clinical study reports.
• A record of scientific impact through publications presentations patents external partnerships or implementation of innovative technologies.
• Experience mentoring scientists or leading matrixed translational teams.

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Companys long-term incentive program.

Subject to the terms of their respective policies and date of hire employees are eligible for the following time off benefits:

• Vacation 120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado 48 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year
• Holiday pay including Floating Holidays 13 days per calendar year
• Work Personal and Family Time - up to 40 hours per calendar year
• Parental Leave 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave 80 hours in a 52-week rolling period10 days
• Volunteer Leave 32 hours per calendar year
• Military Spouse Time-Off 80 hours per calendar year

The anticipated base pay range for this position is: $117000 - $195125

For additional general information on Company benefits please go to: - & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please email the Employee Health Support Center () or contact AskGS to be directed to your accommodation resource.

#LI-Onsite

Required Skills:

Preferred Skills:

Biomarkers Clinical Trials Operations Coaching Critical Thinking Drug Discovery Development Industry Analysis Interdisciplinary Work Medical Compliance Medical Technology Organizational Project Management Organizing Program Management Quality Standards Safety-Oriented Scientific Research Technologically Savvy Translational Medicine

The anticipated base pay range for this position is :

$117000.00 - $201250.00

Additional Description for Pay Transparency:

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).



This position is eligible to participate in the Companys long-term incentive program.



Subject to the terms of their respective policies and date of hire employees are eligible for the following time off benefits:

Vacation 120 hours per calendar year

Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado 48 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year

Holiday pay including Floating Holidays 13 days per calendar year

Work Personal and Family Time - up to 40 hours per calendar year

Parental Leave 480 hours within one year of the birth/adoption/foster care of a child

Bereavement Leave 240 hours for an immediate family member: 40 hours for an extended family member per calendar year

Caregiver Leave 80 hours in a 52-week rolling period10 days

Volunteer Leave 32 hours per calendar year

Military Spouse Time-Off 80 hours per calendar year

For additional general information on Company benefits please go to: - Experience:

Staff IC