Principal Investigator LCMS Scientist

Principal Research Scientist LC-MS/MS Bioanalysis

Everett Washington Relocation Assistance Available

RPM ReSearch has partnered with a leading preclinical Contract Research Organization (CRO) to identify a Principal Research Scientist LC-MS/MS to join its growing bioanalytical sciences team. Our client partners with pharmaceutical and biotechnology companies to support the discovery and development of novel therapeutics through high-quality GLP bioanalytical services. This is an opportunity to join a collaborative scientific organization where your expertise will directly contribute to advancing new therapies toward the clinic.

Important Qualification

Experience supporting Antibody-Drug Conjugate (ADC) bioanalysis is required for this position.

While we welcome applicants with strong LC-MS/MS backgrounds this particular opportunity requires prior experience developing validating and/or supporting LC-MS/MS methods for ADCs within a GLP pharmaceutical or CRO environment. Candidates without ADC experience are unlikely to be a match for this role.

About the Role

As the Principal Research Scientist you will serve as the technical and scientific expert for LC-MS/MS bioanalysis with particular emphasis on ADCs and large molecule assays. Youll provide scientific leadership across method development validation sample analysis study execution and client interactions while collaborating closely with cross-functional scientific and regulatory teams in a GLP environment.

Key Responsibilities

• Provide scientific leadership for LC-MS/MS bioanalysis supporting both small and large molecule programs including ADCs.
• Lead method development validation troubleshooting and sample analysis for GLP bioanalytical studies.
• Serve as Principal Investigator or lead scientist on client-sponsored studies.
• Partner directly with pharmaceutical and biotechnology clients providing technical expertise and scientific consultation.
• Prepare and review scientific reports study documentation and laboratory records.
• Ensure compliance with GLP regulations FDA guidance SOPs and quality standards.
• Collaborate with Quality Regulatory and laboratory teams to support successful study execution and continuous process improvement.

Qualifications

The successful candidate will have:

• Bachelors Masters or Ph.D. in Chemistry Biology Immunology or another relevant scientific discipline.
• Significant hands-on experience with LC-MS/MS instrumentation and bioanalytical method development.
• Demonstrated experience supporting Antibody-Drug Conjugate (ADC) bioanalysis.
• Experience working within a GLP-regulated CRO or pharmaceutical environment.
• Experience serving as a Principal Investigator Senior Research Scientist or comparable scientific leadership role.
• Strong scientific writing data interpretation and client communication skills.
• Ability to manage multiple studies while maintaining exceptional scientific quality and regulatory compliance.

Preferred Experience

Experience with one or more of the following is highly desirable:

• Large molecule LC-MS/MS assays
• Shimadzu and/or SCIEX instrumentation
• Watson LIMS
• FDA ICH M10 guidance
• Bioanalytical method validation in support of drug development

Why Join

• Join a respected and growing preclinical CRO supporting innovative pharmaceutical and biotechnology companies.
• Play a highly visible scientific leadership role with direct client interaction.
• Work on cutting-edge therapeutics including Antibody-Drug Conjugates and other advanced modalities.
• Collaborate with an experienced team of scientists in a GLP environment committed to scientific excellence.
• Competitive compensation comprehensive benefits and relocation assistance are available for qualified candidates.

Interested

Apply directly or send your résumé to:

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