Principal Engineer, AISoftware Support, Pooled Screening Core, Cell & Genetic Medicines

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Remote (US) Spring House Pennsylvania United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for Principal Engineer AI/Software Support Pooled Screening Core Cell & Genetic Medicines to be remote in the US.

Purpose: Johnson & Johnson Innovative Medicine is seeking a Principal Engineer to serve as a senior hands-on technical leader within the CAR Screening & Lead Selection team (CSLS). This individual will design build and scale the software data and AI capabilities that support complex high-throughput cell therapy discovery across pooled and arrayed screening workflows. The Principal Engineer will partner with scientists automation engineers computational scientists and technology teams to connect experimental design laboratory execution data capture analysis visualization and decision-making through scalable digital workflows. The successful candidate will move fluidly between technical strategy and implementation establish robust software architecture and engineering practices and directly deliver production-quality applications APIs data pipelines computational tools and AI-enabled solutions. The role is remote-eligible within the United States and requires approximately 1015% travel to company sites including Spring House Pennsylvania La Jolla California and Cambridge Massachusetts.

You will be responsible for:

• Serve as the senior software and AI technical expert for Cell & Genetic Medicines high-throughput screening capabilities both pooled and arrayed.
• Define and implement scalable architecture connecting laboratory automation analytical instruments enterprise systems scientific data and user workflows.
• Build reliable applications APIs data pipelines computational tools and user-facing visualization solutions for cell therapy discovery.
• Develop and deploy AI-enabled capabilities including machine learning generative AI retrieval-augmented generation and agentic workflows where they provide clear scientific or operational value.
• Proactively identify and prioritize opportunities to apply AI or software solutions that improve organizational effectiveness scientific productivity operational efficiency and decision-making.
• Translate complex experimental processes and scientific questions into intuitive maintainable and reproducible digital solutions.
• Help organize and contextualize screening data construct information assay metadata and analytical outputs to improve experimental planning data quality hit identification candidate ranking and knowledge capture.
• Establish engineering best practices for architecture development testing documentation version control deployment observability security and lifecycle management.
• Build trusted cross-functional and cross-departmental partnerships across Discovery Research IT Business Technology and other groups; align stakeholders clarify expectations and communicate decisions risks tradeoffs and progress constructively.
• Influence technical direction without direct authority and mentor scientists and engineers in software engineering data architecture and the responsible use of AI.

Qualifications/Requirements:

Required

• Bachelors degree in computer science software engineering data science computational biology bioinformatics engineering or a related technical field with significant relevant industry experience; an advanced degree is preferred.
• Extensive experience designing and delivering complex software systems in scientific engineering biotechnology pharmaceutical or similarly data-intensive environments.
• Demonstrated experience integrating AI/ML or generative AI models into usable production-quality software systems.
• Experience using Amazon Web Services (AWS) including provisioning and managing compute instances and working with Amazon S3 buckets for secure data storage access and transfer.
• Strong systems thinking and the ability to rapidly understand scientific workflows and translate user needs into scalable technical solutions.
• Excellent communication stakeholder management and relationship-building skills including the ability to manage both projects and expectations across organizational boundaries.
• Ability to work effectively in highly collaborative multidisciplinary teams and travel approximately 1015% annually.

Preferred

• Experience supporting drug discovery cell therapy functional genomics high-throughput screening or laboratory automation.
• Experience integrating robotic systems analytical instruments and automated data-generation platforms with software and informatics infrastructure.
• Familiarity with high-dimensional biological datasets FAIR data principles scientific metadata standards data governance and regulated or highly controlled technology environments.
• Experience developing scientific applications visualization tools knowledge systems workflow orchestration or AI agents.
• Hands-on experience with electronic laboratory notebook (ELN) software especially Benchling including integrating ELN workflows with scientific data platforms laboratory systems or automation.
• Experience embedded in laboratory-facing organizations and partnering directly with experimental scientists.

What Success Looks Like

Success means creating a connected data-driven screening environment in which scientists spend less time moving and reconciling data experiments are easier to design and reproduce and software and AI capabilities help teams extract insights from large screening campaigns and select stronger therapeutic candidates. The Principal Engineer will provide the technical and collaborative foundation needed to scale pooled and arrayed screening integrate emerging technologies and make screening data an accessible organizational asset.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment as well as get a parents consent for the background check.

#LI-Remote

Required Skills:

Preferred Skills:

The anticipated base pay range for this position is :

$117000.00 - $201250.00

Additional Description for Pay Transparency:

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).



This position is eligible to participate in the Companys long-term incentive program.



Subject to the terms of their respective policies and date of hire employees are eligible for the following time off benefits:

Vacation 120 hours per calendar year

Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado 48 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year

Holiday pay including Floating Holidays 13 days per calendar year

Work Personal and Family Time - up to 40 hours per calendar year

Parental Leave 480 hours within one year of the birth/adoption/foster care of a child

Bereavement Leave 240 hours for an immediate family member: 40 hours for an extended family member per calendar year

Caregiver Leave 80 hours in a 52-week rolling period10 days

Volunteer Leave 32 hours per calendar year

Military Spouse Time-Off 80 hours per calendar year

For additional general information on Company benefits please go to: - Experience:

Staff IC