Postdoctoral Scholar, Immunogenicity

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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for a Postdoctoral Scholar Immunogenicity to be located in Spring House PA.

Purpose: A current gap exists in the ability of preclinical models to accurately predict clinical immunogenicity and anti-drug antibody (ADA) rates and its impact (e.g. safety and efficacy) on therapeutic biologics. Bioanalytical Discovery & Development Sciences (BDDS) department within the Preclinical Sciences & Translational Safety (PSTS) organization at Johnson &Johnson is seeking a postdoctoral scholar to develop and scientifically validate in vitro and immune organoid models for preclinical immunogenicity assessment of therapeutic biologics. To pair with data generated by in vitro models the postdoc will work with colleagues to develop a database to aid in immunogenicity assessment via reverse engineering through comprehensive drug-specific datasets. Successful development of these novel immunogenicity tools will aid in the identification and development of safer and more efficacious biologics.

In this position the postdoctoral scholar will lead assay development and optimization of novel in vitro immunogenicity models demonstrate proof of concept of in vitro immunogenicity models and author SOPs. The postdoc will work cross-functionally with colleagues from PSTS clinical pharmacology discovery translational safety and other relevant organizations to enable broader adoption of in vitro tools (in vitro and bioinformatic) as part of the preclinical development strategy.

You will be responsible for:

• Leading the design development and optimization of in vitro models enabling immunogenicity assessments of therapeutic biologics (e.g. MAPPs immune organoids organ-on-a-chip etc).
  
• Collaborating with cross-functional teams (PSTS clinical pharmacology discovery data sciences translational science and external partners) to build a comprehensive drug-specific database.
  
• Attending technical seminars workshops or conferences for improving practical or technical knowledge and enabling completion of project objectives.
  
• Producing and maintaining clear technical documentation including electronic notebooks and SOPs to support reproducibility and technology dissemination.
  
• Communicating findings through written reports presentations and contributions to manuscripts.
  

Qualifications/Requirements

Education:

• A PhD in Immunology Bioengineering Immuno-Oncology or a related field is required.
  

Experience and Skills:

Required:

• Handson experience developing and optimizing immunoassays (e.g. ELISA ELISpot/FluoroSpot Flow Cytometry or related) measuring immune responses is required.
  
• Primary immune cell culture experience: short- and long-term mammalian immune cell culture primary immune cell isolation from tissue or primary fluids (e.g. whole blood cerebrospinal fluid) and primary immune cell differentiation is required.
  
• Demonstrated record of immunology-related publications is required.
  
• Excellent written and verbal communication skills; ability to work in crossfunctional teams and present technical results to diverse audiences is required.
  
• Strong interpersonal & collaborative skills with an ability to operate as part of a team in a highly interdependent environment is required.
  
• Must be adaptable responsive and committed to completing tasks in a timely fashion.
  

Preferred:

• Experience with 3D cell culture systems such as but not limited to organoids and/or organ-on-a-chip is preferred.
  
• Experience developing or conducting in vitro vaccination and/or in vitro PBMC expansion assays is preferred.
  
• Familiarity with bioanalytical platforms for ultrasensitive detection and an understanding of their strengths/limitations such as LC/MS and Immunopeptidomics is preferred.
  

Other:

• This role may require up to 10% travel a needed.
  

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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