Postdoctoral Fellow-MSH

Salary: $74692

Department: Microbiology

Physical work location: 1468 Madison Avenue New York New York 10029

Name PI or Supervisor: Gustavo Palacios PhD

Web link to Lab: link to Department: Contact: Molly Deroy

Details of Research Project:

The Palacios Laboratory is recruiting multiple motivated Postdoctoral Fellows to join a dynamic collaborative research team working across complementary programs in emerging-virus research including DOORs VITAL and REVISE within EVOLVE. Together these efforts seek to identify and validate critical virus-host dependencies engineer safer and more durable immune protection and develop precision strategies that create virus-resistant cellular states while preserving normal host biology. Projects integrate experimental virology functional genomics receptor and antigen engineering immunology multi-omics and in vivo validation to advance broadly applicable countermeasures against persistent respiratory and emerging viral threats. Individual project assignments will be matched to each fellows expertise and program needs.

Key Responsibilities:

1. Experimental Design & Implementation
2. Data Analysis & Integration
3. Project Management & Collaboration
4. Publication & Presentation

Perform virological and immunological assays under BSL-2 and BSL-3 conditions including cell-based ex vivo organoid and in vivo studies with viruses relevant to pandemic preparedness persistent infection and emerging disease.

Generate analyze and integrate multi-omics functional-genomics immunological and virological datasets to connect molecular mechanisms with infection immune protection and host-cell fitness.

Collaborate with computational biology teams to prioritize host dependencies receptor variants and immunogen designs and to support AI/ML-guided closely with teams at ISMMS and partnering institutions coordinating experiments sharing data and aligning research efforts. Participate in cross-functional meetings to report progress address challenges and contribute to strategy discussions.

Prepare and publish research findings in high-impact scientific journals.

Present research at conferences and program review meetings.

Technical Duties:

• Mammalian cell culture and viral propagation
• Viral entry replication neutralization and challenge assays
• CRISPR-based gene editing and receptor/function validation
• Flow cytometry CyTOF and cellular immune profiling
• ELISA ELISPOT Western blotting and qPCR
• Multi-omics sample preparation and data interpretation
• Mouse or other relevant preclinical model work

Educational and other Requirements for the position:

PhD in Virology Immunology Microbiology Molecular Biology Cell Biology Bioengineering or a related field.

• Expertise in virology with hands-on experience in viral culture cell-based assays and host-pathogen interaction studies.
• Experience in one or more of the following areas is preferred: functional genomics or gene editing; vaccine or antigen engineering; cellular immunology; multi-omics; organoid systems; or animal models.
• Familiarity with BSL-2 and BSL-3 laboratory practices.
• Strong communication skills and the ability to work within a multidisciplinary team.

Experience Required: MD or PhD

Goals/Outcomes of the Research Project:

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74692.00 - $80000.00 Annually. Actual salaries depend on a variety of factors including experience education and operational need. The salary range or contractual rate listed does not include bonuses/incentive differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs) 815 - Microbiology - ISM Icahn School of Medicine