Grad Co-op — Computational Safety Modeling for Small Molecules

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer heart disease inflammatory conditions rare diseases and obesity and obesity-related conditions. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Grad Co-op Computational Safety Modeling for Small Molecules

Lets do this. Lets change the world. We are seeking a graduate co-op to help expand our computational toolbox for assessing the safety of small molecule drug candidates and potentially other modalities. Working with computational scientists and nonclinical safety experts you will contribute to a strategy that provides useful predictions early in drug discovery and brings experimental evidence into the assessment as it becomes available.

This role combines scientific data assessment model development and collaboration with the researchers who use safety information to guide compound design and testing. The specific toxicity endpoints will be selected with the team based on scientific need and the quality of available data.

What you will do

• Identify curate and compare relevant external and internal data including chemical structures assay results and exposure information where available
• Develop and evaluate approaches suited to each question. These may include structural alerts analogue-based read-across machine learning and models that integrate experimental results with other safety evidence
• Evaluate performance on compounds relevant to the intended use and document context of use uncertainty applicability and important limitations
• Work with computational scientists medicinal chemists and toxicologists to explore how model outputs can guide compound prioritization and follow-up experiments
• Present results and deliver reproducible analyses documented model prototypes and recommendations for further development
• Provide mechanisms for retraining as additional data is generated over time

• Must be available to work a part-time schedule.
• Expected continued enrollment in an accredited college or university following the internship program / co-op
• Student must be located in the United States for the duration of the internship program

We are all different yet we all use our unique contributions to serve patients. The individual we seek is a team player with these qualifications:

Basic Qualifications:

Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:

• 18 years or older
• Graduated with a bachelors degree from an accredited college or university
• Currently enrolled in an MBA program for an MBA internship OR a Masters program for a Masters internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Masters OR Pharm D OR Ph.D. program before the internship starts

Preferred Qualifications:

• Currently pursuing a graduate degree in cheminformatics bioinformatics computational chemistry or biology data science statistics toxicology or a related field
• Experience using Python to analyze scientific data
• Familiarity with statistical modeling and machine learning including the principles of model evaluation
• Ability to communicate technical findings clearly and work with scientists from different disciplines
• Experience with cheminformatics predictive toxicology or analysis of in vitro assay data
• Familiarity with small molecule drug discovery or nonclinical safety assessment
• Experience combining data from multiple sources and documenting reproducible computational workflows
• Familiarity with version control and collaborative software development

As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $35.34 - $41.20 per hour.

• Build a network of colleagues that will endure and grow throughout your time with us and beyond.
• Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
• Participate in executive and social networking events as well as community volunteer projects.

In any materials you submit you may redact or remove age-identifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Salary Range