Executive Director, Data Science and Bioinformatics (CVRM)

We harness digital data science & AI to fast-forward our research. Making sure work born in a lab can make a real patients lives across the world.

About the role

Provide globalTherapyAreaandDataand AI leadershipandexpertisespanningenterprise enablement and R&D bioinformatics within CVRMbringing deepexpertisein at least one domain and the ability to lead across a multidisciplinary ecosystem.

Develop and deliver multi-year Data & AI strategies that accelerate target discovery translational insights biomarker strategies and clinical development while aligning with AZs cross-functional business agenda.

Lead the conversion ofmulti-modal data (genomics transcriptomics proteomics metabolomics single-cell imaging EHR/RWD wearable/digital biomarkers) into decision-gradeinsightsthrough multidisciplinary teams and scalable capabilitiesthrough multidisciplinary teams and scalable capabilities.

Operates globally with enterprise scope; sit on the Early CVRM Leadership Team and contribute materially to Early CVRM global AI strategy

Accountabilities

• Global strategy and portfolio alignment:Define and implement long-term Data & AI strategies for Early CVRM R&D within an enterprise framework; ensure alignment with global cross-functional priorities program goals and portfolio governance forums.
• R&D bioinformatics leadership:Lead the analytical approach from discovery through developmenttarget identification/validation disease segmentation mechanistic and predictive modelling biomarker discovery and responder identificationlinking insights to clinical trial optimization.
• AI/ML advancement and governance: Champion responsible fit-for-purpose AI/MLDrive adoption of advanced AI/ML approaches (-based models agentic workflows)leveraginginternal and externalexpertise.
• Data foundations and standards:Shape enterprise data strategy and principles (FAIR etc.) in partnership with data engineering and platform teams.
• Global operational leadership: Translate strategy into operational plans and delivery across regions; set the annual operating budget and ensuretimelydelivery of outcomes within approved levels. Drive continuous improvementautomationanddigitalisationwith a high-performance culture.
• Cross-functional and translational partnership:Oversee and guide development of predictive and mechanistic models and ML approaches toidentifypotential responders andoptimizestudy designs to generate novel endpoints and biomarkers for clinical studies and drive disease state understanding. Oversee analytical support for exploratory analyses of interventional clinical trial datasets and analyses of observational/mechanistic/experimental medicine clinical study datasets to derive insights on efficacy safety and biomarker correlations related to targets/drug programs in the Early CVRM portfolio.
• External leadership and partnerships: Represent AZ with academia consortia CROs/technology partners and at conferences;identifyand execute strategic partnerships that accelerate scientific and enterprise outcomes.
• Leadership: Build mentor and inspire a multidisciplinary team (bioinformatics computational biology data science/ML data engineering). Performancemanagesenior managers plan succession and coach senior talent

Essential requirements:
Education:

PhD (preferred) or equivalent advanced degree inbioinformatics computational biology statistics computer science applied mathematics biomedical engineering or related field

Leadership:

8years experienceleadingbioinformatics/data science organizationsin biotech/pharma including people leadership org design hiring and coaching

Domaindepth:

Demonstrated impactinCVRM-relevant biology(e.g. obesity diabetes heart failure CKD MASH atherosclerosis) and/or deep translational/clinical application of omics and real-world data.

Technicalbreadth:

Strong background inone or moreof thefollowingareas with workingknowledgeacross others:multi-omics analysis statistical methods ML and modern computational practices (e.g. cloud/HPC workflow orchestration versioning and scalable data processing).

Experiencewithor exposuretocontemporarytransformer-based AI architectures

Drug development mindset:Experience influencing decisions across the R&D lifecycle including target validation biomarker development patient stratification and clinical endpoint strategy.

Communication &influence:

Proven ability to communicate complex analyses to executive and cross-functional audiences; strong stakeholder management and collaboration skills.

Complianceawareness:

Familiarity with data privacy ethical AI considerations and regulated environments (as applicable to clinical data and patient information).

Desirable requirements

Experienceincomplexglobalorganizations

Scientific credibility:Track record of high-impact contributions ( patents major program milestones platformlaunches orwidely adopted methods).

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work atpaceand challenge we work on averagea minimum of three days per week from the thatdoesntmeanwerenot flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $ -Annual USD. Base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility toparticipatein our equity-based long-term incentive program. Benefits offered include a qualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coveragein accordance withtheterms and conditions of the applicable plans.

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.