Director, Program Management

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life increasing potential duration of life and resolving serious unmet medical needs. At Summit we believe in building a team of world class professionals who are passionate about this mission and it is our people who drive this mission to reality. Summits core values include integrity passion for excellence purposeful urgency collaboration and our commitment to people. Our employees are truly the heart and soul of our culture and they are invaluable in shaping our journey toward excellence.

Summits team is inspired to touch and help change lives through Summits clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies including:

Non-small Cell Lung Cancer (NSCLC)

• HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

• HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

• HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

• HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than Chinas National Medical Products Administration (NMPA). Summit is headquartered in Miami Florida and has additional offices in California New Jersey the UK and Ireland.

Our Mission

To build a viable long-lasting health care organization that assumes full responsibility for designing developing trial enrollment regulatory approval and commercializing patient physician caregiver payor and societal friendly medicinal therapy intended to improve quality of life increase potential duration of life and resolve serious medical healthcare needs. We will accomplish this by building a team of world-class scientists and business administrators that apply themselves to this mission.

We have in-licensed Ivonescimab (PD-1/VEGF Bispecific Antibody SMT112) which is a novel potential first-in-class investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. We have ongoing phase-III clinical studies in multiple indications including NSCLC and CRC.

Overview

The Director of Program Management provides strategic and operational leadership across multiple development programs driving alignment between Research Development Business Strategy Manufacturing and execution. This role plays a critical part in advancing collaboration programs across the portfolio and enabling long-term value creation from development through regulatory approval.

The Director serves as the primary point of contact for key programs to executive leadership ensures disciplined program governance and strengthens the Program Management function as the organization scales. This position reports to the VP Program Management and may have people leadership responsibility.

Role and Responsibilities

Strategic Program Leadership

• Responsible for overall execution of multiple programs to deliver on program objectives and maximize value.

• Partner with executive leadership on program strategy

• Define and oversee major milestones decision points objectives and inflection points across programs

• Lead scenario planning trade-off analyses and decision frameworks to support executive decision-making

• Ensure alignment across Development Regulatory Manufacturing and Corporate Strategy

Cross-Functional & Executive Leadership

• Lead and integrate complex cross-functional workstreams across Research Development Regulatory and Manufacturing

• Facilitate effective decision-making and accountability across global teams and external partners in collaboration with Alliance Management.

• Present clear insights recommendations and program status to C-suite and senior leadership
• Mentor and develop Program Managers and strengthen organizational capability

Program Execution & Governance

• Oversee end-to-end program execution including activation of new indications postGo decision

• Ensure consistent application of program management standards dashboards and governance models

• Chair timely efficient and action-oriented team meetings to coordinate operations and communications.

• Review and validate integrated program plans timelines and metrics for accuracy and strategic alignment

• Represent Program Management on senior governance forums and key internal or external teams

Timelines & Scenario Planning

• Oversee integrated program timelines aligned with enterprise goals

• Partner with functional leaders on budgets and forecast planning

• Ensure data integrity and transparency in executive reporting

Risk Opportunity & Continuous Improvement

• Identify and manage program risks and mitigation strategies

• Communicate risks opportunities and trade-off s clearly to executive leadership

• Drive continuous improvement of program management processes tools and operating models

• Lead strategic initiatives to mature the Program Management function as the company grows
• All other duties as assigned

Experience Education and Specialized Knowledge

• Bachelors degree and minimum 12 years of relevant project management/scientific experience within the pharmaceutical industry; OR a MS or MBA and minimal 10 years of relevant experience; OR a PhD in a scientific field or a PharmD DVM or MD degree with 6 years of relevant experience

• 1012 years of pharmaceutical or biotech industry experience with progressive responsibility in program or portfolio management

• Extensive pharmaceutical drug development experience required;

• Prior solid tumor oncology experience including late-stage development and registrational trials required

• Demonstrated success leading complex global cross-functional programs and influencing senior executives

• Experience with managing alliances and external partners strongly preferred

• Proven ability to balance strategic leadership with operational execution

• Exceptional communication facilitation and presentation skills

• Strong proficiency in program management and planning tools (e.g. MS Office Project Smartsheet)

• Willing to travel for key meetings.

Actual compensation packages are based on several factors that are unique to each candidate including but not limited to skill set depth of experience certifications and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus stock benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summits Talent Acquisition team atto obtain prior written authorization before referring any candidates to Summit.

Summit Therapeutics an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment. We do not discriminate in recruitment hiring training or promotion or any other employment practices for reasons of race color religion gender national origin age sexual orientation marital or veteran status disability or any other legally protected status.