Director, Pharmacometrics
Job Location:
San Diego, CA - USA
Yearly Salary:
Posted:
Application Deadline:
Vacancies:
Job Summary
Job Title: Director Pharmacometrics
Location: San Diego or Remote U.S.
Job Type: Full-Time
Who We Are
Avenzo Therapeutics Inc. (Avenzo or Company) is a clinical-stage biotechnology company focused on developing next-generation oncology therapies for patients. The Company was co-founded in 2022 by Drs. Athena Countouriotis and Mohammad Hirmand (former CEO and CMO of Turning Point Therapeutics Inc. respectively). Our team is passionate about and committed to advancing a pipeline of potentially differentiated targeted oncology programs that make a difference in the lives of people with cancer. The Company is headquartered in San Diego California.
Position Summary
Reporting to the VP Clinical Pharmacology the Director Pharmacometricswill lead the development and execution of pharmacometrics strategies supporting Avenzos oncology programs. This role is responsible for applying model-informed drug development approaches including population PK PK/PD and exposure-response modeling to guide dose optimization study design and regulatory decision-making. The Director will collaborate across functions and with external partners to generate quantitative insights that enable efficient clinical development and support regulatory submissions and interactions.
Essential Job Functions and Responsibilities
- Provide strategic leadership and subject matter expertise in pharmacometrics and clinical pharmacology across our development portfolio
- Develop and execute model-informed drug development strategies including population PK PK/PD exposure-response and simulation analyses to support program decision-making
- Lead pharmacometric activities and contribute clinical pharmacology expertise as a core member of cross-functional program teams partnering closely with Clinical Development Biometrics Regulatory Affairs and other internal and external subject matter experts
- Develop and apply pharmacometric analyses to support dosing recommendations for special populations dose modifications drugdrug interactions organ impairment and other intrinsic and extrinsic factors
- Resolve complex scientific and technical challenges with cross-program impact contributing to dose justification benefit-risk assessments and regulatory development strategies
- Analyze and interpret clinical and translational PK/PD data and oversee pharmacometric modeling activities to inform development and regulatory decisions
- Develop clinical pharmacology plans and dosing strategies from first-in-human studies through late-stage clinical development
- Author and review clinical pharmacology content for protocols clinical study reports regulatory submissions briefing documents and health authority interactions
- Represent Clinical Pharmacology and Pharmacometrics in regulatory agency meetings and responses supporting global development and registration strategies
- Provide oversight of pharmacometric platforms modeling environments reporting workflows and external vendors to ensure high-quality and efficient execution
- Manage pharmacometrics activities budgets timelines and deliverables to ensure successful program execution
- Influence development strategy through quantitative analyses and scientific recommendations that support portfolio-wide objectives
Preferred Qualifications
- PhD degree in pharmacometrics biological/pharmaceutical sciences bioengineering biostatistics engineering data science or a related disciplines with 8 years of progressive pharmacometrics experience in the life sciences industry or an equivalent combination of academic and industry experience
- Demonstrated expertise in population PK/PD exposure-response and model-informed drug development approaches
- Extensive hands-on experience with pharmacometric software platforms including NONMEM Monolix R and other industry-standard modeling and simulation tools
- Deep understanding of clinical pharmacology and pharmacometric requirements for regulatory submissions including IND NDA MAA and NDS filings
- Proven experience leading and authoring modeling and simulation plans and directing pharmacometric analyses across Phase IIV clinical development programs
- Strong knowledge of oncology drug development clinical pharmacology principles and regulatory guidelines
- Demonstrated ability to manage multiple priorities projects and deliverables through influence matrix leadership and effective stakeholder engagement
- Excellent communication and interpersonal skills with the ability to collaborate effectively with internal and external stakeholders
- Strong analytical and problem-solving abilities with a strategic mindset
- This position requires periodic/regular travel including up to 15% of work time which may include overnight travel
Physical Demands and Work Environment
Physical Demands:
- Constant or continuous use of a computer keyboard monitor and mouse to perform a variety of tasks
- Constant or frequent sitting standing or walking
- May lift and/or move objects of various weights
Work Environment:
- Remote: Home office; expected to travel to and work from the Companys headquarters in San Diego from time to time
- San Diego-based: On-site requirement (Monday through Thursday)
- Noise level in the work environment is usually moderate
- Fast-paced time-sensitive environment with frequently changing priorities
- Handle multiple projects simultaneously
Reasonable accommodations may be provided to enable qualified individuals with disabilities to perform the essential functions of the position.
Salary Range
The salary range for this position is $234000 to $250000 per year. The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and years of experience within the job and the industry education and skills and certifications.
Benefits
Provided they meet all eligibility requirements under the applicable plan documents employees (and their eligible dependents) will be eligible to enroll in group healthcare plans that offer medical dental vision and basic life and AD&D insurance. Additional benefit programs include short-term and long-term disability insurance flexible spending accounts health savings accounts and voluntary insurance programs including voluntary life AD&D accident and critical illness. Employees will also be able to enroll in the Companys 401(k) addition employees will accrue 10 hours of paid vacation time every month and accrue 1 hour of paid sick leave for every 30 hours worked. Employees also enjoy 17 paid holidays each calendar year including a winter closure subject to applicable Company policies. All benefits are subject to the terms and conditions of the applicable plan documents and Company policies which may be amended from time to time.
Other Compensation
The hired candidate will be eligible to receive an annual discretionary bonus and an equity award subject to the terms of the applicable employment agreement plan documents and Company policies.
The information above is intended to provide a general description of benefits and other compensation and is not a substitute for applicable plan documents or company policies.
Applications for this position are anticipated to close on November 30 2026. For more information about this posting please contact.
Equal Employment Opportunity
Avenzo is committed to providing equal employment opportunities to all employees and applicants without regard to an individuals actual or perceived protected characteristic or characteristics or any combination of protected characteristics including race (including traits associated with race such as hair texture and protective hairstyles including braids locks and twists) ethnicity religion religious creed (including religious dress and grooming practices) color sex (including childbirth breast feeding and related medical conditions) gender gender identity or expression sexual orientation national origin ancestry citizenship status uniformed service member and veteran status marital status pregnancy age (40 and over) protected medical condition (including cancer and genetic conditions) genetic information disability (mental and physical) reproductive health decision-making medical leave or other types of protected leave (requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act) the employee or their family members status as a victim of a qualifying act of violence political activity or affiliation use of cannabis off the job and away from the workplace association with an individual who has or is perceived to have a protected characteristic or characteristics or any combination of protected characteristics or any other protected status in accordance with all applicable federal state and local laws.
Notice to Search Firms/Third Party Agencies
Avenzo does not accept unsolicited resumes from recruiters employment agencies or search firms without a valid executed search agreement in place.
Required Experience:
Director
