Chief of Staff and Strategic Program Management

Phathom Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of gastrointestinal (GI) diseases. With exclusive rights in the United States Europe and Canada to vonoprazana first-in-class potassium-competitive acid blocker (PCAB)Phathom is working to transform the treatment of acid-related disorders.

Our current portfolio includes:

• VOQUEZNA (vonoprazan) tablets approved for the treatment of heartburn associated with Non-Erosive GERD as well as the healing and maintenance of healing of Erosive GERD
• VOQUEZNA TRIPLE PAK (vonoprazan tablets amoxicillin capsules clarithromycin tablets) and VOQUEZNA DUAL PAK (vonoprazan tablets amoxicillin capsules) approved for the treatment of H. pylori infection in adults

Beyond our commercialized products we are advancing a pipeline focused on innovative treatments for other acid-related GI disorders including Eosinophilic Esophagitis (EoE).

At Phathom we are fueled by innovation driven by purpose and united by a shared commitment to improving patient outcomes. Our team comprises seasoned GI and industry experts with proven track records of delivering groundbreaking therapies including anti-secretory agents. Together we are tackling unmet medical needs and working hard to enhance the lives of patients.

We seek motivated innovative problem-solvers who excel in fast-paced collaborative environments and are eager to make an impact. At Phathom youll find more than a career youll join our Phamily where employees feel empowered valued and inspired to do their best work.

In August 2026 we proudly earned the distinction of being Great Place to Work certified for the third year in a row with 92% of surveyed employees affirming that Phathom is an exceptional workplace.

Ready to help change the landscape in GI Join us and be part of something extraordinary.

Our CEO sets the strategic agenda. This role makes sure it lands.

As Chief of Staff and Strategic Program Management you will be the execution counterpart to the CEO the person who takes our most important initiatives from intent to completion. Some are led by the CEO directly. Others are led by members of our Leadership both cases you are the connective tissue: the one person with a complete current view of what is moving what is stuck and what needs a decision.

This is a high-visibility high-trust seat with unusual breadth. You will sit close to strategy Board and investor work and you will touch every function in the company. It is also a hands-on role without a team behind it. You will build the trackers write the briefs run the meetings and chase the commitments yourself. If that combination is energizing rather than daunting read on.

What you will do

Own how our key initiatives progress. Hold the master view milestones owners dependencies risks and decision points regardless of which executive leads the work. Run the cadence that keeps it current and honest.

Drive work forward across the Leadership Team. You will not have authority over the people doing the work. You will have clarity credibility and the CEOs confidence. Pursue commitments without friction surface slippage before it becomes a surprise and clear obstacles that sit between functions.

Represent the CEO. Stand in where his intent needs to be present. Carry it faithfully and know the difference between a decision you can make one you should shape and one you bring back.

Prepare the CEO. Make sure he enters every Leadership Team meeting Board session investor conversation and key external meeting with the right material the right framing and the right questions.

Design our operating rhythm. Leadership Team meetings quarterly reviews and offsites agendas that force the real conversation pre-reads that respect peoples time decisions captured actions closed.

Build with AI. Use AI aggressively and intelligently to compress synthesis drafting analysis and tracking and bring others along by showing them what is now possible. We expect this role to model what a modern operating function looks like.

Take on what lands on a CEOs desk. Analyses diligence support competitive reviews and the range of one-off work that needs a capable and trusted owner.

This role is based at our Florham Park New Jersey headquarters on a hybrid schedule with three days per week onsite. The job runs on presence and relationships so candidates should be located within a reasonable commute of Florham Park.

Five or more years of demonstrated ownership of complex multi-workstream initiatives the full arc from framing through to completion.

A track record of influencing senior stakeholders without authority and of holding executives to their commitments in a way that strengthens the relationship rather than straining it.

Direct experience working with presenting to or supporting C-suite leaders.

Real fluency with AI tools and a conviction that they change how work gets done.

Meticulous attention to detail paired with a strong bias toward action.

Clear concise writing with the ability to produce executive- and Board-ready material.

Sound judgment and absolute discretion with confidential information.

A Bachelors degree.

Strong candidates often come from a top-tier strategy or management consulting firm or from program leadership in a commercial pharmaceutical biotech or comparably regulated environment. Experience in a small publicly traded company is a plus as is an advanced degree but neither is required.

At Phathom we prioritize the total well-being of our Phamily members. Our commitment is reflected in a competitive employee benefits package designed to support employees and their families overall well-being now and in the future including:

• Highly competitive medical dental and vision coverage options with low monthly premiums
• Roth & Traditional 401(k) savings plan with annual employer match
• Long-term incentive equity compensation program
• Employee Stock Purchase Plan (ESPP)
• Comprehensive paid leave programs including:
• 16 weeks of paid parental leave for all new parents
• 4-week part-time Bridge-Back-to-Work Program
• Hybrid and Flex Working Arrangements
• Unlimited Time Off
• 17 paid company holidays in addition to a year-end winter shutdown period

Other Benefits:

• Annual Fitness & Wellbeing Reimbursement
• Company-provided Life and Accidental Death & Dismemberment (AD&D) insurance
• Company-provided short and long-term disability benefits
• Company-funded HSA plan
• Accident and Hospital Indemnity insurance
• Employee Assistance Program (EAP)
• Employee recognition program

The expected annual base salary range for this role is $235000 - $300000.

Phathom is an equal opportunity employer that is committed to inclusion and diversity and provides equal opportunity for all applicants without regard to race color religion sex sexual orientation gender identity national origin disability Veteran status or other legally protected characteristics.

Applicants with a disability who require a reasonable accommodation for any part of the application interview or hiring process can contact us by sending an email to .

Required Experience:

Senior IC