Automated Antibody Engineering Scientist

At IDEXX the ability to rapidly develop high-quality antibody reagents is foundational to advancing pet health diagnostics. The Reagent Discovery team is the critical bridge between biomarker discovery and immunoassay development and this role sits at the center of that pipeline. As a Scientist II you will drive the molecular biology and antibody generation workflows that move novel biomarkers from target sequence to validated reagent directly enabling new diagnostic tools for the veterinarians and pet owners we serve.

• You will need direct experience with molecular biology techniques including primer design gene synthesis cloning strategies and recombinant construct development for antibody expression.

• You have designed and executed workflows for antibody generation using recombinant antibody expression display technologies or a combination of platforms.

• You are comfortable working across the full bench workflow from sequence analysis and construct design through transfection expression and basic protein characterization.

• You have worked cross-functionally with discovery and assay development teams communicating experimental data clearly and aligning with stakeholders on project timelines.

• You are organized and detail-oriented with the ability to advance multiple concurrent projects in a fast-paced environment.

• Design and execute molecular biology workflows for antigen and antibody construct development including primer design PCR-based cloning site-directed mutagenesis and sequence verification.

• Develop and optimize recombinant expression constructs using mammalian insect or bacterial systems to support high-throughput antigen production.

• Devise and execute antibody generation workflows including platform selection immunization or display screening and hit confirmation.

• Perform protein and antibody characterization utilizing standard biochemical techniques including SDS-PAGE Western blot ELISA BLI and analytical SEC.

• Develop and maintain automated liquid handling protocols to increase throughput and reproducibility across molecular biology and screening workflows.

• Collaborate with LC/MS and genomics teams to evaluate incoming biomarker targets and establish feasible antigen design and production strategies.

• Partner with downstream immunoassay development teams to communicate reagent performance data define acceptance criteria and meet delivery milestones.

• Generate clear concise presentations and communicate progress updates to cross-functional audiences.

• Leverage published literature to identify novel molecular biology antibody generation and expression technologies applicable to the Reagent Discovery pipeline.

• Document experiments and maintain accurate electronic records. Adheres to appropriate safety procedures and regulatory requirements.

• A degree in Molecular Biology Biochemistry Immunology or a related discipline Candidates should possess a Bachelors with 5-7 years of relevant laboratory experience Masters with 3-5 years experience of relevant laboratory experience.

• Strong hands-on experience with molecular biology techniques including primer design PCR restriction enzyme cloning Gibson assembly site-directed mutagenesis and sequence analysis is a must.

• Experience with recombinant protein or antibody expression in mammalian insect or bacterial systems is a must.

• Familiarity with standard protein characterization techniques (e.g. SDS-PAGE analytical SEC Western blot ELISA).

• Familiarity with laboratory automation platforms (e.g. Hamilton Tecan Biomek or similar liquid handling systems).

• Experience in protein purification utilizing AKTA FPLC or similar instruments is a plus.

• Experience in antibody discovery platforms such as hybridoma technology phage display or single B-cell cloning is a plus.

• Background in immunoassay development or in vitro diagnostics is a plus.

• Working knowledge of binding assay technologies such as BLI or SPR is a plus.

• Ability to work independently and collaboratively toward a unifying set of goals.

• Strong analytical problem-solving and communication skills are a must.

• Organizational skills and ability to plan and prioritize work across multiple projects are a must.

• Takes initiative and is accountable; detail-oriented and adaptable to shifting priorities.