Associate Scientist II, in vitro Preclinical Development

AbbVie is seeking a driven and innovative Associate Scientist II in vitro Preclinical Development to join the mRNA-tLNP group. The Associate Scientist II in vitro Preclinical Development will develop and perform cell-based assays to generate data that advance mRNA-tLNP pipeline programs from early discovery through IND-enabling studies

• Execution in vitro assays to evaluate mRNA-tLNP-mediated T-cell reprogramming including assessment of cytotoxicity T-cell effector function and flow cytometry based immune cell phenotyping.
• Isolate PBMCs and T cells from leukopaks.
• Use aseptic techniques to culture mammalian cells including tumor cell lines T cells and PBMCs.
• Make stable tumor cell lines using techniques such as electroporation viral delivery and nanoparticle transfections.
• Perform routine tasks competently and independently and generate reliable and consistent results.
• Demonstrate skill in multiple techniques and appropriately modify protocols as required to suit the changing needs of research or development sciences.
• Maintain and implement good laboratory practice including an accurate online laboratory notebook system instrument and reagent validation and personal safety precautions.
• Work collaboratively in a cross-functional team environment. Organize and communicate data (written and oral) and participate in project team meetings. with an emphasis on applications in oncology and autoimmune diseases.

Qualifications :

• Bachelors Degree or equivalent education with typically 3 or more years experience or Masters Degree or equivalent education (no additional experience) in immunology cell and molecular biology or related field.
• Previous experience in chimeric antigen receptor (CAR) production and evaluation is desirable.
• Experience with aseptic/sterile techniques culturing of mammalian cells including cell lines T cells and PBMCs.
• Experience with viral and non-viral gene transfer techniques to engineer mammalian cells.
• Experience designing and executing assays to assess T cell function including cytotoxicity activation proliferation and cytokine profiling.
• Proficiency in flow cytometry and data processing.
• Experience designing and executing plate-based assays including ELISA and Luminex/MSD.
• Experience with scientific data analysis software including CellEngine and Tableau is highly preferred.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat  the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors  including  geographic location and we may ultimately  pay more or less than the posted range. This range may be  modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to  participate in our short-term incentive programs.  

Note: No amount of pay is  considered to be wages or compensation until such amount isearned  vested  and determinable. The amount and availability of  any bonus commission incentive benefits or any other form of compensation and benefits that areallocable to a   particular employee  remains in the Companys sole and absolute discretion unless and until paid and may be  modified at the Companys sole and absolutediscretion  consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time