Associate Director, U.S. Tax Operations & Reporting

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) a serious liver disease that can progress to cirrhosis liver failure need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigals medication Rezdiffra (resmetirom) is a once-daily oral liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic inclusive and high-performing culture that values scientific excellence operational rigor and collaboration. To support our continued growth we are strengthening our workforce strategy to ensure we have the right talent at the right time in the right way.

Reporting to the Executive Director Tax the Associate Director U.S. Tax Operations & Reporting will be accountable for Madrigals U.S. tax operations and global tax reporting infrastructure including ASC 740 tax reporting U.S. compliance financial statement and tax authority audit readiness SOX-aligned controls tax technology enablement and external advisor management. This hands-on role requires a tax professional who can independently drive work from planning through execution deliver audit-ready work product bring clear recommendations to senior leadership and translate complex tax matters into practical business guidance for Finance and business partners.

Key Outcomes for Success

• Deliver accurate timely audit-ready quarterly and annual tax reporting under ASC 740 including the tax provision UTPs effective tax rate Form 10-K/10-Q disclosures and documentation supporting key judgments.

• Convert tax risks and technical analyses into concise recommendations options and decision points for senior leadership and business partners.

• Build capacity and operational leverage within the Tax function by leading external advisors and cross-functional workstreams with clear priorities accountability and continuous improvement.

• Establish a scalable well-governed tax operating model that strengthens controls improves efficiency and supports the Companys continued growth.

• Advance the Tax functions technology and data capabilities by leveraging automation system enhancements and scalable digital solutions to improve efficiency reporting accuracy and business insights.

Key Responsibilities

Tax Provision and Financial Statements

• Own the quarterly and annual ASC 740 income tax provision process including effective tax rate analysis deferred tax inventory valuation allowance assessment uncertain tax positions and tax-related balance sheet accounts.

• Direct the tax close calendar deliverables workpapers review process tax footnotes disclosures quarterly reviews and annual audit support to deliver timely accurate public company reporting.

• Own technical tax accounting conclusions for complex and non-routine matters directing preparation of supporting memoranda and presenting recommendations to the Executive Director Tax and Finance leadership.

• Drive alignment with Corporate Accounting International Finance FP&A Treasury and external auditors on forecasting cash tax projections reporting requirements and key tax accounting judgments.

U.S. Tax Compliance Operations & Audit Support

• Oversee U.S. federal state local Puerto Rico and applicable indirect tax compliance processes including estimated payments extensions returns information reporting and other required filings.

• Govern the tax compliance calendar risk register documentation protocols escalation processes and external service provider model to ensure deadlines are met deliverables meet quality standards and risks are visible early.

• Lead review of tax audit workpapers information request responses and supporting documentation to ensure technical accuracy completeness and alignment with Company tax positions; escalate judgment items and recommended responses to the Executive Director Tax

• Team with advisors on execution for U.S. international tax reporting and related calculations including Subpart F GILTI/net CFC tested income FDII/foreign-derived deduction-eligible income foreign tax credits transfer pricing inputs and related compliance considerations.

• Drive R&D credit analysis documentation process coordination and audit readiness in partnership with tax advisors and operational business stakeholders.

• Monitor legislative and regulatory developments and advise on impacts to the Companys tax provision compliance profile cash taxes and operational tax processes.

Tax Technology Controls & Process Infrastructure

• Establish and enhance tax controls policies process narratives documentation and operating procedures to support SOX compliance audit readiness and scalable public company reporting.

• Define tax requirements and lead tax implementation for ERP tax provision indirect tax reporting compliance tracking and workflow automation initiatives in partnership with Accounting IT and external advisors.

• Define and execute process improvements that reduce manual processes improve data quality accelerate close and compliance timelines and increase reliability of tax reporting outputs.

Cross-Functional Business Advisory & Strategic Support

• Advise Finance and business leaders on tax reporting and operational matters translating complex tax requirements into business impact risk tradeoffs and recommended next steps

• Drive alignment with internal and external stakeholders to ensure transfer pricing policies intercompany flows and operational processes are implemented consistently and supported by appropriate documentation.

• Champion continuous improvement across the Tax function by identifying opportunities to simplify processes strengthen governance and enhance the effectiveness of tax operations through scalable solutions.

Required & Desired Qualifications

• Bachelors degree in Accounting or a related field required; Masters in Taxation or related advanced degree preferred; CPA required.

• 10 years of progressive corporate tax experience ideally including a combination of Big Four/public accounting and in-house public company multinational corporate tax experience.

• Deep expertise in public company ASC 740 income tax accounting U.S. corporate taxation financial statement disclosures and tax-related SOX controls.

• Hands on experience leading complex quarterly and annual income tax provisions for multinational corporations including ETR analysis deferred taxes valuation allowances uncertain tax positions and financial statement disclosures.

• Strong experience with U.S. federal state local Puerto Rico and indirect tax compliance tax audit support and workpaper review and U.S. international tax reporting and operational matters including NCTI FDDEI FTCs and related calculations.

• Experience with tax technology ERP systems and process automation initiatives; OneSource Tax Provision and indirect tax engine experience such as Vertex or OneSource Indirect Tax preferred.

• Proven ability to own technical tax analyses manage external advisors and financial statement auditors and communicate complex tax matters to senior leaders and non-tax stakeholders.

Core Competencies

• Ownership and independent judgment: Leads complex high-impact work with minimal oversight synthesizes technical and business considerations into actionable recommendations and exercises sound judgment in balancing risk compliance and business objectives.

• Operational Rigor: highly organized deadline-driven and able to manage multiple priorities without compromising quality.

• Communication: able to distill complex tax issues into concise business impact options recommendations decisions needed and timing.

• Leadership & Influence: Builds credibility and influences decisions across functions. Effectively aligns stakeholders navigates competing priorities and drives execution through collaboration sound judgment and executive presence.

• Strategic Thinking: Anticipates emerging risks and opportunities evaluates long-term implications and develops scalable solutions that support the Companys growth and evolving business needs.

Madrigals Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

All employees receive equity which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidates qualifications skills education experience business needs and market demands. As of the date of this posting a good faith estimate of the current pay scale for this position applicable to all candidates is $166500 - $203500 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits including flexible paid time off medical dental vision and life/disability insurance and 401(k) offerings (i.e. traditional Roth and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance legal services and other addition we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal state and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance please contact

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications merit and business need. Applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin age disability protected veteran or disabled status or other characteristic protected by applicable federal state or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

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