AI Engineer

What if the work you did every day could impact the lives of people you know Or all of humanity

At Illumina we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person in every role has the opportunity to make a difference. Surrounded by extraordinary people inspiring leaders and world changing projects you will do more and become more than you ever thought possible.

Location

San Diego CA onsite 5 days/week.

Not open to remote.

Position Summary

Illumina is searching for an AI Engineer with 1-2 years of hands-on AI enterprise engineering experience who is passionate about building with modern AI and ready to grow into the next generation of AI specialists. You will work alongside senior and principal engineers to build ship and improve production AI features learning the craft of applied AI engineering on real systems that serve real users.

This role is hands-on from day one. You will write code prototype ideas evaluate models integrate APIs and contribute to the platform that powers AI across the organization. You will be supported with strong mentorship clear scope and the room to grow into more senior responsibilities over time.

Key Responsibilities

Build and Ship

• Implement features in production AI applications including LLM integrations prompt workflows retrieval pipelines and supporting backend services.
• Develop and maintain components of RAG systems including data ingestion chunking embedding generation and retrieval logic.
• Write clean tested well-documented Python code that meets team standards for quality and maintainability.
• Build internal tools scripts and prototypes that accelerate the teams ability to experiment and iterate.

Evaluate and Improve

• Run experiments to evaluate model performance prompt variations retrieval strategies and end-to-end system behavior.
• Develop and maintain evaluation datasets test cases and regression checks for AI features.
• Analyze production logs and metrics to identify quality issues latency bottlenecks and cost optimization opportunities.
• Contribute to incident response and root-cause analysis for AI system issues.

Learn and Contribute

• Stay current with the AI ecosystem by following research exploring new tools and bringing useful ideas back to the team.
• Participate actively in code reviews design discussions and team rituals asking questions and offering perspectives.
• Document your work clearly so that teammates can build on it and learn from it.
• Pair with senior engineers on complex problems and gradually take on larger scope as you grow.

Collaborate

• Work closely with product managers designers and other engineers to understand requirements and ship features that solve real user problems.
• Communicate progress blockers and trade-offs clearly in standups written updates and design documents.
• Support other teams by answering questions about AI capabilities and limitations.

Required Qualifications

• 1 to 2 years of professional software engineering experience (internships co-ops and substantial open source contributions count).
• Bachelors degree in Computer Science Data Science Machine Learning Engineering or a related field or equivalent demonstrable experience.
• Strong programming skills in Python with familiarity in writing modular testable code.
• Working knowledge of how large language models behave in practice including experience calling LLM APIs (OpenAI Anthropic Google or open-weight models) in at least one project.
• Familiarity with at least one of the following: RAG systems prompt engineering vector databases embeddings or basic agent patterns.
• Solid foundation in software engineering basics including Git REST APIs JSON SQL and at least one cloud environment.
• Strong written and verbal communication skills with a willingness to ask questions and engage in technical discussion.

Preferred Qualifications

• Experience with at least one AI framework such as LangChain LlamaIndex Hugging Face Transformers or DSPy.
• Exposure to vector databases (Pinecone Weaviate pgvector Vertex AI Vector Search) and embedding models.
• Familiarity with one major cloud platform (GCP Azure or AWS) particularly the managed AI services.
• Comfort with Docker basic CI/CD workflows and modern engineering practices.
• A portfolio of personal projects open source contributions hackathon work or coursework that demonstrates curiosity and initiative in AI.
• Experience with web frameworks (FastAPI Flask) or frontend basics (React TypeScript) is a plus but not required.
• Coursework or self-directed learning in machine learning deep learning NLP or information retrieval.

Technical Skill Profile

• Core Programming:Python (required) familiarity with JavaScript or TypeScript helpful.
• AI Tooling:Comfort calling LLM APIs basic prompt engineering familiarity with at least one framework (LangChain LlamaIndex Hugging Face).
• Data and Storage:SQL JSON basic familiarity with vector databases and traditional databases.
• Cloud and Engineering:Git REST APIs basic Docker at least one cloud environment (GCP Azure or AWS).
• Bonus:Notebook environments (Jupyter Colab) evaluation tools (RAGAS LangSmith Weights and Biases) basic frontend development.

Competencies We Value

• Curiosity:Genuine interest in how AI works and a habit of digging into details rather than treating models as black boxes.
• Ownership:Willingness to see problems through even when the path is unclear.
• Communication:Comfort asking questions sharing progress and explaining your thinking.
• Quality Mindset:Pride in writing code that is clear tested and easy for others to work with.
• Learning Velocity:A track record of picking up new tools languages and concepts quickly.
• Collaboration:Generosity with teammates openness to feedback and willingness to help others succeed.

#LI-ONSITE

The estimated base salary range for the AI Engineer role based in the United States of America is: $98400 - $147600. Should the level or location of the role change during the hiring process the applicable base pay range may be updated accordingly. The range reflects longterm growth in the role; therefore most candidates are hired between the minimum and middle of the range. Placement depends on experience skills location and internal equity. Additionally all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work including access to genomics sequencing family planning health/dental/vision retirement benefits and paid time off.

We are a company deeply rooted in belonging promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation Illumina has always prioritized openness collaboration and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay regardless of gender ethnicity or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences increase cultural awareness and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex race creed color gender religion marital status domestic partner status age national origin or ancestry physical or mental disability medical condition sexual orientation pregnancy military or veteran status citizenship status and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local state and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local state and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process please contact To learn more visit: The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.