Senior Scientist I, Biotherapeutic Production Technologies

The Role:

Location: Andover MA

Generate:Biomedicines is seeking an experienced Senior Scientist I to independently lead complex protein production and characterization efforts in support of drug discovery and platform initiatives.

This individual-contributor role will work across upstream construct and expression strategy mammalian and cell-free protein production downstream purification and fit-for-purpose analytical characterization. You will define technical approaches integrate data acrossworkflows and make recommendations that enable confident scientific decisions across multiple protein modalities and stages of work.

You will serve as a technical point of contact for protein purification and characterization strategy partnering with cross-functional teams and external collaborators to align material quality scale timelines and downstream requirements. You will also help advance scalable data-rich workflows that improve throughput reproducibility and organizational learning.

Heres how you will contribute:

• Independently define plan and execute complex protein production purification and characterization strategies across multiple discovery and platform initiatives. Establish technical milestones decision criteria dependencies and risk-mitigation plans.
• Lead the design optimization scale-up and troubleshooting of protein expression workflows including transient mammalian and cell-free protein synthesis platforms. Provide technical input into construct design molecular biology and stable-expression activities as needed.
• Lead purification workflow development from capture through polishing with particular emphasis on larger-scale or later-stage protein production. Design and interpret chromatography screening studies including predictor-plate approaches resin selection operating-condition optimization and scale translation.
• Produce high-quality protein material across a range of formats and scales. Partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use.
• Select apply and interpret appropriate analytical and biochemical characterization methods to assess protein purity identity concentration oligomeric state aggregation stability and other relevant quality attributes.
• Integrate expression purification and characterization data to identify root causes resolve complex technical challenges evaluate trade-offs and recommend next steps. Clearly communicate the evidence assumptions risks and uncertainty supporting technical decisions.
• Serve as a technical point of contact for protein production purification and characterization strategy. Influence cross-functional decisions by translating scientific findings into clear recommendations for discovery platform analytical and data-focused partners.
• Lead technical interactions with CROs CDMOs vendors and other external partners as appropriate including defining technical work packages supporting method or process transfer reviewing data troubleshooting issues and ensuring that deliverables meet scientific requirements.
• Drive the development of scalable reproducible and well-documented workflows. Advance the thoughtful use of automation high-throughput approaches structured experimental data and AI/ML-enabled tools to improve scientific productivity and learning.
• Develop and share new methods technical standards and best practices. Advise and mentor colleagues provide constructive scientific feedback and contribute to an inclusive collaborative and high-performing team.
• Demonstrate accountability for scientific quality and delivery by tracking progress proactively surfacing risks and communicating successes setbacks and lessons learned with clarity and transparency.

The Ideal Candidate will have:

• Independently define plan and execute complex protein production purification and characterization strategies across multiple discovery and platform initiatives. Establish technical milestones decision criteria dependencies and risk-mitigation plans.
• Lead the design optimization scale-up and troubleshooting of protein expression workflows including transient mammalian and cell-free protein synthesis platforms. Provide technical input into construct design molecular biology and stable-expression activities as needed.
• Lead purification workflow development from capture through polishing with particular emphasis on larger-scale or later-stage protein production. Design and interpret chromatography screening studies including predictor-plate approaches resin selection operating-condition optimization and scale translation.
• Produce high-quality protein material across a range of formats and scales. Partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use.
• Select apply and interpret appropriate analytical and biochemical characterization methods to assess protein purity identity concentration oligomeric state aggregation stability and other relevant quality attributes.
• Integrate expression purification and characterization data to identify root causes resolve complex technical challenges evaluate trade-offs and recommend next steps. Clearly communicate the evidence assumptions risks and uncertainty supporting technical decisions.
• Serve as a technical point of contact for protein production purification and characterization strategy. Influence cross-functional decisions by translating scientific findings into clear recommendations for discovery platform analytical and data-focused partners.
• Lead technical interactions with CROs CDMOs vendors and other external partners as appropriate including defining technical work packages supporting method or process transfer reviewing data troubleshooting issues and ensuring that deliverables meet scientific requirements.
• Drive the development of scalable reproducible and well-documented workflows. Advance the thoughtful use of automation high-throughput approaches structured experimental data and AI/ML-enabled tools to improve scientific productivity and learning.
• Develop and share new methods technical standards and best practices. Advise and mentor colleagues provide constructive scientific feedback and contribute to an inclusive collaborative and high-performing team.
• Demonstrate accountability for scientific quality and delivery by tracking progress proactively surfacing risks and communicating successes setbacks and lessons learned with clarity and transparency.

Education and Experience

• Ph.D. in biochemistry molecular biology bioengineering chemical engineering protein sciences or a related discipline with typically 4 or more years of relevant industry experience; orB.S. or M.S. in a relevant scientific or engineering discipline with typically 12 or more years of relevant industry experience; orAn equivalent combination of education and experience that demonstrates the technical depth independent judgment and scope of impact required for the role.

Nice to Have

• Experience with stable-expression systems and stable cell-line development activities.
• Experience with construct design cloning vector design or related molecular-biology workflows.
• Experience working with engineered proteins multispecifics novel scaffolds or other complex protein modalities.
• Experience integrating protein design information into expression purification or characterization strategies.
• Experience with automation high-throughput experimentation laboratory information systems or structured experimental-data environments.
• Experience managing technical work conducted by CRO CDMO or vendor partners.
• Experience developing workflows or methods that were adopted beyond an immediate project or work group.

Who Will Love This Job:

This is an opportunity to shape how Generate produces characterizes and learns from protein material in a modern data-rich discovery environment. Your work will directly influence critical scientific decisions while improving the speed quality scale and reproducibility of workflows used across discovery and platform initiatives.

You will combine hands-on science with meaningful technical ownership broad cross-functional collaboration and the opportunity to develop approaches that enable the advancement of next-generation biologics.

About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creationone grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation this approach aims to reduce the uncertainty time and cost associated with developing protein-based medicines.

Founded in 2018 we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need faster guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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