Senior Scientist, Bioconjugation

Senior Scientist Bioconjugation
Location: Discovery Centre Biomedical Campus Cambridge UK

Competitive salary package and benefits

Introduction to the Role:

This is an exciting opportunity for a laboratory-based scientist to join the Oncology Targeted Discovery (OTD) Bioconjugation and Analytical team in Cambridge. You will become part of a growing team of Bioconjugation scientists and play a pivotal role in the delivery of robust and high-quality data to support drug discovery projects within the Oncology portfolio. Working collaboratively with other disciplines across AstraZeneca you will have the opportunity to contribute to the research and development for early phase projects. You should have a background in Oncology/Biology/Chemical Biology and a strong passion for experimental work and delivering data from the laboratory. You will use your scientific judgement strong ability to analyse experimental data and use effective communication skills to contribute to decision making for early-stage drug discovery programmes. As a Bioconjugation Scientist youll have a deep understanding of the range of analytical procedures relating to bioanalysis/bioscience. You will expertly design and conduct laboratory projects/experiments develop analytical methods and generate interpret and report scientific data to relevant stakeholder.

What youll do

• Develop optimise and scale up drug discovery research lab experiments independently by applying the techniques of Bioconjugation of small molecules to antibodies and related scaffolds
• Perform routine interpretation of data with little or no guidance with a clear understanding of its implications within drug discovery and effectively communicate to relevant stakeholders in a clear and concise manner
• Works independently within a team and collaboratively with internal and external stakeholders
• Maintains a well-developed understanding of approaches to targeted delivery of therapeutics within Oncology
• Remain up to date with relevant recent advances and relevant technology including published papers/patents with peers
• Authoring and reviewing relevant documents including laboratory notebooks protocols and reports
• Ensures own work and work of peers follows Good Laboratory Practice Safety Health and Environment (SHE) standards and all other relevant internal AstraZeneca standards and external regulations

Skills and Experience

• PhDinChemistry Biochemistry Bioengineering or a related scientific discipline.
• Alternatively anMSc or BScin a relevant discipline withsignificant industrial experiencein bioconjugation protein chemistry or a closely related field.
• Strong foundation in synthetic chemistry and protein biochemistry with the ability to apply this knowledge to the design and execution of bioconjugation strategies.
• Hands-on experiencein protein and bioconjugate characterisation using techniques such asUV/Vis spectroscopyHPLCincludingsize-exclusion chromatography (SEC)hydrophobic interaction chromatography (HIC)andion exchange chromatography (IEX) as well asLC-MS.
• Experience inpreparative purification workflows including the use ofÄKTA systemsandtangential flow filtration (TFF)for purification and processing of proteins and bioconjugates.
• Demonstrated track record inprotein or related scaffold modification including the successful execution of conjugation strategies and evaluation of resulting constructs.
• Ability toplan prioritise and execute experiments independently while maintaining high scientific rigour attention to detail and strong data integrity standards.
• Strong written and verbal communication skills with the ability to present technical data and conclusions clearly to both specialist and cross-functional audiences.

Desirables:

• Strong understanding of thedevelopment optimisation and qualification of robust analytical methodsfor protein and bioconjugate characterisation.
• Direct experience working withantibody-drug conjugates (ADCs)or related targeted conjugate modalities.
• Experience withhigh-throughput techniquesor automated workflows in a relevant scientific area.
• Knowledge ofbiophysical characterisationof proteins and conjugates including assessment of stability aggregation and higher-order properties.

Why AstraZeneca

At AstraZeneca were dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. Theres no better place to make a difference to medicine patients and society. An inclusive culture that champions diversity and collaboration and always committed to lifelong learning growth and development. Were on an exciting journey to pioneer the future of healthcare.

So whats next

• Are you already imagining yourself joining our team Good because we cant wait to hear from you.
• Are you ready to bring new ideas and fresh thinking to the table Brilliant! We have one seat available and we hope its yours.

Where can I find out more

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