Senior Scientist (12-Month Fixed Term Contract), Oncology Research

Senior Scientist(12-MonthFixed Term Contract) Oncology Research

Location: Cambridge (Discovery Centre)

Introduction to the Role:

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial thinking big and working together to make the impossible a reality.Werepassionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring bignew ideasto life.

Are you ready to work on one of the most excitingOncologypipelines in industry

About the Role:

AstraZenecas vision in Oncology is to push the boundaries of science to change the practice of medicine transform the lives of patients living with cancer and toultimately eliminatecancer as a cause of death.

We areseekingahighly motivatedSenior Scientistwith deep scientific and technicalexpertisespanning both adaptiveand innateimmune cell biologywitha track recordof scientific excellence to joinImmune Cell Engagers Discoveryteamin Cambridge UKfora12-monthperiod. As a Senior Scientistyou will be a key member of a team focused on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practicalexpertisein immunology toestablishassay systems and deliver datasets that will have direct impact onimmune-oncology research projects.

Main Duties and Responsibilities

Working in this laboratory-based position within the Immune Cell Engagers Discoverygroupyou will develop design conduct and analysein-vitroand/orex-vivoexperiments to assess the function of our candidate drugs and helpusto dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will also review emerging literature and internal data to help inidentifyingnew potential targets and contribute to target validation activities.

A strong foundationin immunology / immuno-oncology andan in-depthtechnicalexpertisefor the analysis of immune function and phenotype is essential for this role. As a highlyorganisedandself-motivated individual with a strong lab/practical background you will stay up to date with relevant technical and intellectual scientificexpertisein tumour immunology and have a genuine passion for this field of research!

Essential Requirements

• A PhD or equivalent experience in immunology/Immuno-oncology/cancer biology.

• Extensive background in immunology and/orimmuno-oncology.

• Experience of a range ofin-vitroandex-vivotechnicalskills for the analysis of human immune cell functionsviamultiparameter flow cytometry ELISA/multiplex assaysELISPOTprimary immune cellisolation andco-culturescell killing assays(likeTDCC ADCC CDC ADCP)TILsisolation andphenotyping.

• Molecularbiology skills includinggene expression analysis and stable cell line generation.

• Working experience with immune cellassaysand/orcharacterization is highly desirable.

• Strong interpersonal influencing negotiating and collaboration skills together with evidence of having used theseskillsto support problem solving andindelivering theprojects ina collaborative environment.

• Depth of understanding andstrongenthusiasm for immunology and immuno-oncology.

• Proventrack recordofscientific accomplishmentsasevidentfrom publications/patents.

• Data processing statisticalanalysisand interpretation.

• Experienceinpreparing written scientific reports (e.g.manuscripts) and oral presentations (e.g.slides posters).

• Ability to record protocols and experimentsin a timely mannerandmaintainan excellent electronicnotebook(eLNB).

Desirable Requirements

• We encourage applications from candidates who haveexperience in the evaluation of immunecellfunctionsandindevelopingand deployingcomplex immunological assaysto understand the MOA of novel therapeutics.

• Expertisein fieldsof T-cell engagersT cell exhaustion tumour myeloid and/or NK biology.

• Experienceinvisualizing/quantifyinghigh content multi-parameter flowcytometrydata/transcriptomic datasets.

• Candidates who candemonstrateproficiencyinleveragingAI technologies including machine learning data analysis and algorithm development to enhance research outcomes alongside strongproblem solvingskills to enable integration of these tools into scientific workflows are strongly preferred.

• Prior experience with spectral flow cytometry.

• Working experience with 3Dcell culture.

• Experienceinworking with patient-derived tumours/TILs

• Knowledge of the drug discovery process.

Why AstraZeneca

Join a company where rigorous science meets real-world impact. You will operate with high visibility and growing responsibility shaping deliverables that influence key decisions across global therapy areas. Expect a collaborative environment that brings diverse minds together uses advanced tools and technology to solve tough problems and recognizes both progress and learning. We balance bold ambition with supportvaluing curiosity resilience and kindnessso you can stretch your skills contribute to breakthroughs and see the patient impact of your work.

So whats next

• Are you already imagining yourself joining our team Good because we cant wait to hear from you. Send your CV today and feel free to add your Cover Letter for us to start reviewing it soon.

Where can I find out more

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