Scientist II

Work Schedule

Environmental Conditions

Job Description

As part of the Thermo Fisher Scientific team youll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the worlds toughest challenges like protecting the environment making sure our food is safe or helping find cures for cancer.

DESCRIPTION

Join our collaborative Antibody Development team at Thermo Fisher Scientific where youll contribute to advancing protein and antibody engineering technologies. As a Scientist II in Protein Biology youll be part of our team focused on designing developing and validating high-quality antibodies using advanced tools and methodologies. Youll contribute to research that enables our customers to make the world healthier cleaner and safer.

In this role youll plan and execute experiments independently driving product development from concept through validation. Youll utilize advanced protein characterization techniques while collaborating across teams to optimize workflows and improve product quality. The position offers opportunities to support junior scientists present research findings and contribute to scientific innovation in a supportive environment dedicated to excellence.

REQUIREMENTS

Education:

• MSc or PhD in Proteomics Analytical Chemistry Biochemistry Biotechnology Structural Biology Immunology Protein Science or a related life sciences discipline. Candidates with an MSc or PhD may be considered without prior industry experience.
• Alternatively a Bachelors degree in a relevant scientific field with a minimum of 2 years of hands-on experience in proteomics mass spectrometry protein characterization or related analytical sciences.

Technical Expertise:

• Strong theoretical and practical expertise in LC-MS/MS-based proteomics including large-scale identification quantification and characterization of proteins and post-translational modifications from complex biological matrices.
• Hands-on experience operating troubleshooting and optimizing high-resolution mass spectrometry platforms (e.g. Waters LC MS/MS Q-TOF Triple Quadrupole) coupled with nanoLC UHPLC or HPLC systems.
• Experience with proteomics workflows including sample preparation protein extraction digestion peptide cleanup fractionation and quantitative proteomics approaches (label-free TMT SILAC DIA PRM/SRM).
• Proficiency in protein purification and characterization using chromatographic techniques such as affinity chromatography ion exchange chromatography size exclusion chromatography (SEC) HPLC and FPLC.
• Experience with protein characterization methods including SDS-PAGE Western blotting ELISA capillary electrophoresis and protein-protein interaction assays.
• Knowledge of biophysical characterization techniques such as Surface Plasmon Resonance (SPR) Bio-Layer Interferometry (BLI) Differential Scanning Fluorimetry (DSF) or related methods is desirable.

Data Analysis and Bioinformatics:

• Proficiency in proteomics data processing and interpretation using industry-standard software platforms (e.g. Proteome Discoverer MaxQuant Skyline DIA-NN Spectronaut PEAKS Scaffold or equivalent).
• Strong understanding of protein databases bioinformatics tools statistical analysis and biological pathway interpretation.
• Experience with data visualization and reporting tools including GraphPad Prism Microsoft Office Suite and statistical software packages.
• Demonstrated ability to design experiments analyze complex datasets troubleshoot technical challenges and draw scientifically sound conclusions.

Molecular and Protein Sciences:

• Experience with antibody discovery characterization engineering or display technologies is advantageous.
• Familiarity with structural biology tools and molecular visualization software (e.g. PyMOL Schrödinger Chimera) is desirable.
• Knowledge of protein conjugation chemistry bioconjugation strategies and antibody modification techniques is considered a plus.

Professional Skills:

• Excellent scientific documentation technical writing and presentation skills with the ability to communicate complex data to multidisciplinary audiences.
• Strong organizational skills with the ability to manage multiple projects and meet timelines in a fast-paced environment.
• Demonstrated ability to work independently while contributing effectively within cross-functional teams.
• Experience mentoring junior scientists technicians or students is desirable.
• Familiarity with regulated laboratory environments including GLP GMP or ISO quality systems is preferred.
• Prior project leadership method development or technology transfer experience is considered an asset.