Research Engineer (LLM Performance), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights faster breakthroughs and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one were building today. It starts with the culture at this company. It starts with you.

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AIs powerful capabilities we can use it to model complex biological phenomena to help design novel molecules anticipate how drugs will perform and develop innovative medicines to treat and cure some of the worlds most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day and with each new breakthrough were getting closer to the promise of digital biology and achieving our ambitious mission to one day solve all disease with the help of AI.

This is an exciting opportunity for you to contribute to frontier research at the intersection of AI and drug design.

Working in a highly creative iterative environment you will join the model performance and scaling team where you will partner with scientists and engineers to scale foundational models that will transform the biopharmaceutical world as we know it.

You will draw upon your existing engineering experience whilst learning from those around you to apply novel techniques and ideas to newly encountered model and systems performance optimizations as well as machine learning computational biology and chemistry problems.

• Implement and optimize LLM post-training methods at scale on frontier models.
• Collaborate with research teams to translate new methods into production-ready systems.
• Relentlessly prioritize and execute on performance optimization opportunities.
• Evaluate and deploy frameworks for supervised fine-tuning reinforcement learning and LLM evaluation.
• Diagnose and fix performance bottlenecks and communication overhead in distributed training and inference systems.
• Deploy low-precision methods to balance performance with accuracy impacting real world drug design programs.

• Significant experience with large scale distributed training of LLMs.
• Experience with deep learning ML frameworks (either JAX or PyTorch).
• Knowledge of parallelism strategies and collective communication libraries (e.g. NCCL).
• Good understanding of GPU architectures. Reasoning about performance concepts is more important than writing kernels from scratch
• Excellent collaboration skills.

• Experience with general LLM serving stacks.
• Knowledge of XLA Triton Pallas CUDA or similar accelerator DSLs / compilers.
• Experience with optimising ML accuracy using low-precision formats.
• Prior experience building deploying and maintaining production systems on GCP.
• Interest in chemistry and biology.

We are guided by our shared values. Its not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful
Thoughtful at Iso is about curiosity creativity and care. It is about good people doing good rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness but its also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. Its a confidence in our hypothesis as well as the urgency and agility needed to deliver on it. Because disease wont wait so neither should we.

Together
Together at Iso is about connection collaboration across fields and catalytic relationships. Its knowing that transformation is a group project and remembering that what were doing will have a real impact on real people everywhere.

We believe that to be successful we need a team with a range of skills and talents. Were building an environment where collaboration is fundamental learning is shared and every employee feels supported and able to thrive. We value unique experiences knowledge backgrounds and perspectives and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex race religion or belief ethnic or national origin disability age citizenship marital domestic or civil partnership status sexual orientation gender identity pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation please do not hesitate to let us know.

Its hugely important for us to share knowledge and build strong relationships with each other and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model and would require you to be able to come into the office 3 days a week (currently Tuesday Wednesday and one other day depending on which team youre in). If you have additional needs that would prevent you from following this hybrid approach wed be happy to talk through these if youre selected for an initial screening call.

Please note that when you submit an application your data will be processed in line with our .

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